S100A10 information

S100A10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A4P, 1BT6, 4DRW, 4FTG, 4HRE, 4HRG, 4HRH
Identifiers
Aliases	S100A10, 42C, ANX2L, ANX2LG, CAL1L, CLP11, Ca[1], GP11, P11, p10, S100 calcium binding protein A10
External IDs	OMIM: 114085; MGI: 1339468; HomoloGene: 2228; GeneCards: S100A10; OMA:S100A10 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,993,859 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	93,471,950 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; synovial joint; ; germinal epithelium; ; synovial membrane; ; trigeminal ganglion; ; amniotic fluid; ; oral cavity; ; olfactory bulb; ; lower lobe of lung; ; jejunal mucosa;
	Top expressed in
	conjunctival fornix; ; external carotid artery; ; belly cord; ; cornea; ; internal carotid artery; ; aortic valve; ; ascending aorta; ; dermis; ; corneal stroma; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; protein homodimerization activity; transmembrane transporter binding; lipid binding;
Cellular component	membrane raft; extrinsic component of plasma membrane; extracellular exosome; endoplasmic reticulum; extracellular region; collagen-containing extracellular matrix;
Biological process	positive regulation of focal adhesion assembly; positive regulation of GTPase activity; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of binding; protein heterotetramerization; membrane raft assembly; vesicle budding from membrane; positive regulation of stress fiber assembly; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	6281
	20194
	ENSG00000197747
	ENSMUSG00000041959
	P60903
	P08207
	NM_002966
	NM_009112
	NP_002957
	NP_033138
	Wikidata
View/Edit Human	View/Edit Mouse

S100 calcium-binding protein A10 (S100A10), also known as p11, is a protein^[5] that is encoded by the S100A10 gene in humans and the S100a10 gene in other species.^[6]^[7] S100A10 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells. They regulate a number of cellular processes such as cell cycle progression and differentiation. The S100 protein is implicated in exocytosis and endocytosis by reorganization of F-actin.^[7]

The p11 protein is linked with the transport of neurotransmitters. Found in the brain of humans and other mammals, it has been implicated in the regulation of mood. In addition, due to its interaction with serotonin-signaling proteins and its correlation with symptoms of mood disorders, p11 is a new potential target for drug therapy.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197747 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041959 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gerke V, Weber K (Nov 1985). "The regulatory chain in the p36-kd substrate complex of viral tyrosine-specific protein kinases is related in sequence to the S-100 protein of glial cells". The EMBO Journal. 4 (11): 2917–20. doi:10.1002/j.1460-2075.1985.tb04023.x. PMC 554598. PMID 2998764.
^ Harder T, Kube E, Gerke V (Apr 1992). "Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family". Gene. 113 (2): 269–74. doi:10.1016/0378-1119(92)90406-F. PMID 1533380.
^ ^a ^b "Entrez Gene: S100A10 S100 calcium binding protein A10".
^ Cite error: The named reference Rosack_2006 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197747 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041959 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2998764-5] Gerke V, Weber K (Nov 1985). "The regulatory chain in the p36-kd substrate complex of viral tyrosine-specific protein kinases is related in sequence to the S-100 protein of glial cells". The EMBO Journal. 4 (11): 2917–20. doi:10.1002/j.1460-2075.1985.tb04023.x. PMC 554598. PMID 2998764.

[pmid1533380-6] Harder T, Kube E, Gerke V (Apr 1992). "Cloning and characterization of the human gene encoding p11: structural similarity to other members of the S-100 gene family". Gene. 113 (2): 269–74. doi:10.1016/0378-1119(92)90406-F. PMID 1533380.

[entrez-7] "Entrez Gene: S100A10 S100 calcium binding protein A10".

[Rosack_2006-8] Cite error: The named reference Rosack_2006 was invoked but never defined (see the help page).

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