Cathepsin B belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in intracellular proteolysis.[5] In humans, cathepsin B is encoded by the CTSB gene.[6][7] Cathepsin B is upregulated in certain cancers, in pre-malignant lesions, and in various other pathological conditions.[8][9][10][11]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021939 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sloane BF (April 1990). "Cathepsin B and cystatins: evidence for a role in cancer progression". Seminars in Cancer Biology. 1 (2): 137–52. PMID 2103490.
^Chan SJ, San Segundo B, McCormick MB, Steiner DF (October 1986). "Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs". Proceedings of the National Academy of Sciences of the United States of America. 83 (20): 7721–5. Bibcode:1986PNAS...83.7721C. doi:10.1073/pnas.83.20.7721. PMC 386793. PMID 3463996.
^Cao L, Taggart RT, Berquin IM, Moin K, Fong D, Sloane BF (February 1994). "Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene". Gene. 139 (2): 163–9. doi:10.1016/0378-1119(94)90750-1. PMID 8112600.
^Tong B, Wan B, Wei Z, Wang T, Zhao P, Dou Y, Lv Z, Xia Y, Dai Y (September 2014). "Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis". Clinical and Experimental Immunology. 177 (3): 586–97. doi:10.1111/cei.12357. PMC 4137842. PMID 24749816.
^Lai WF, Chang CH, Tang Y, Bronson R, Tung CH (March 2004). "Early diagnosis of osteoarthritis using cathepsin B sensitive near-infrared fluorescent probes". Osteoarthritis and Cartilage. 12 (3): 239–44. doi:10.1016/j.joca.2003.11.005. PMID 14972341.
^Ha SD, Ham B, Mogridge J, Saftig P, Lin S, Kim SO (January 2010). "Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm". The Journal of Biological Chemistry. 285 (3): 2120–9. doi:10.1074/jbc.M109.065813. PMC 2804368. PMID 19858192.
^Yang WE, Ho CC, Yang SF, Lin SH, Yeh KT, Lin CW, Chen MK (2016). "Cathepsin B Expression and the Correlation with Clinical Aspects of Oral Squamous Cell Carcinoma". PLOS ONE. 11 (3): e0152165. Bibcode:2016PLoSO..1152165Y. doi:10.1371/journal.pone.0152165. PMC 4816521. PMID 27031837.
CathepsinB belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in intracellular proteolysis...
turnover. Cathepsin A (serine protease) CathepsinB (cysteine protease) Cathepsin C (cysteine protease) Cathepsin D (aspartyl protease) Cathepsin E (aspartyl...
the mucin content of the urethral glands of Littré. Smegma contains cathepsinB, lysozymes, chymotrypsin, neutrophil elastase and cytokines, which aid...
Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. The protein is a cysteine cathepsin, a lysosomal cysteine protease that plays a...
Nitroxoline has been shown to inhibit the enzymatic activity of cathepsinB. CathepsinB degrades extra-cellular membrane proteins in tumor cells, allowing...
family. Cathepsin S is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Cathepsin S is expressed...
software engineering methods Catb.org, the website of Eric S. Raymond CathepsinB, an enzymatic protein Catfish and the Bottlemen, a British indie rock...
PMC 336852. PMID 3041370. "Table 1: The Single Nucleotide Polymorphisms in cathepsinB protein mined from literature (PMID: 16492714)". doi:10.7717/peerj.7425/table-1...
Cathepsin D is a protein that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked...
number of enzymatic reactions. The enzymes involved are proteinases (cathepsins – B, D, H & L, and calpains) and exopeptidases (peptidase and aminopeptidase)...
matrix. Several other cathepsins are expressed in osteoclasts including cathepsinsB, C, D, E, G, and L. The function of these cysteine and aspartic proteases...
1002/14651858.cd010696 "Table 1: The Single Nucleotide Polymorphisms in cathepsinB protein mined from literature (PMID: 16492714)". PeerJ BIOINFORMATICS...
of progressive myoclonic epilepsy (EPM1). Cystatin B has been shown to interact with CathepsinB. GRCh38: Ensembl release 89: ENSG00000160213 – Ensembl...
Cathepsin G is a protein that in humans is encoded by the CTSG gene. It is one of the three serine proteases of the chymotrypsin family that are stored...
(1998) report the inner mucosa contains apocrine glands, which secrete cathepsinB, lysozyme, chymotrypsin, neutrophil elastase, and hormones such as androsterone...
Cathepsin C (CTSC) also known as dipeptidyl peptidase I (DPP-I) is a lysosomal exo-cysteine protease belonging to the peptidase C1 protein family, a subgroup...
Sharma R, Bhat B, Shrivastava A, Chinthakindi M, Singh A (2019). "Structural, functional and molecular dynamics analysis of cathepsinB gene SNPs associated...
extracellular matrix. Both CathepsinB, MMP-1 and MMP-3 have been found to be increased in Alzheimer's disease (AD) and cathepsinB is increased in multiple...
Inhibitors of Endocytosis, Endosomal Acidification, Structural Integrity, and Cathepsin (B and L) Activity". oxfordjournals.org. The Journal of Infectious Diseases...
October 2019). "Structural, functional and molecular dynamics analysis of cathepsinB gene SNPs associated with tropical calcific pancreatitis, a rare disease...
metabolism of some drugs in the body. It is also an inhibitor of human cathepsinB. Amentoflavone has a variety of in vitro activities including antimalarial...
showed that adducts form between RAPTA compounds and proteins (especially cathepsinB and thioredoxin reductase(TrxR)). Moreover, the reactivity of RAPTA in...
fused with lysosomes and lysosomal cysteine proteases, particularly cathepsinB, start to break down valine-citrulline linker and MMAE is no longer bound...
Retrieved 2021-02-11. "Table 1: The Single Nucleotide Polymorphisms in cathepsinB protein mined from literature (PMID: 16492714)". doi:10.7717/peerj.7425/table-1...