isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
keratinocyte differentiation
cornification
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3713
16447
Ensembl
ENSG00000163207
ENSMUSG00000049128
UniProt
P07476
P48997
RefSeq (mRNA)
NM_005547
NM_008412
RefSeq (protein)
NP_005538
NP_032438
Location (UCSC)
Chr 1: 152.91 – 152.91 Mb
Chr 3: 92.48 – 92.48 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Involucrin of squamous epithelia N-terminus
Identifiers
Symbol
Involucrin_N
Pfam
PF10583
InterPro
IPR019571
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Involucrin repeat
Identifiers
Symbol
Involucrin
Pfam
PF00904
InterPro
IPR000354
SCOP2
1eu0 / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Involucrin repeat
Identifiers
Symbol
Involucrin2
Pfam
PF06994
InterPro
IPR009733
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Involucrin is a protein component of human skin and in humans is encoded by the IVL gene.[5][6] In binding the protein loricrin, involucrin contributes to the formation of a cell envelope that protects corneocytes in the skin.
^ abcGRCh38: Ensembl release 89: ENSG00000163207 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000049128 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Eckert RL, Green H (August 1986). "Structure and evolution of the human involucrin gene". Cell. 46 (4): 583–9. doi:10.1016/0092-8674(86)90884-6. PMID 2873896. S2CID 39293076.
Involucrin is a protein component of human skin and in humans is encoded by the IVL gene. In binding the protein loricrin, involucrin contributes to the...
is thought to be caused by a mutation in the gene encoding the protein involucrin. The first case of FDCWD was reported in 1972. Since then, there have...
and some parts of hair strands. It serves as a scaffold protein, with involucrin, in cell envelope organization. The trichohyalin gene is produced and...
keratin 5, keratin 10, and keratin 14, but also other markers such as involucrin, loricrin, transglutaminase, filaggrin, and caspase 14. In humans, it...
expression of keratinocyte transglutaminase, ornithine decarboxylase, involucrin, epidermal growth factor receptor, and various keratins. More than 99%...
IVL may refer to: The IATA code for Ivalo Airport Involucrin, a human gene Ilmailuvoimien Lentokonetehdas, a Finnish defense, aviation and aerospace company...
formed by cross-linking of soluble precursor proteins such as loricrin, involucrin, envoplakin and periplakin. The overall integrity of the stratum corneum...
and a range of differentiation-specific structural proteins, such as involucrin, loricrin, filaggrin, and small proline-rich proteins, in the formation...
protein can also form cross-links to all other CE proteins including involucrin, envoplakin, keratin, repetin, desmoplakin, SPR1, SPR2, and LEP. TCHH-TCHH...
S2CID 9108586. Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte...
specific maturation factors (MHCII, Aire, CD80, TRA) and initiation of involucrin expression, marker of terminally differentiated epithelium. Remaining...
Shinohara T, Chylack LT, Akagi Y, Singh DP (2002). "Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived...
epidermis, the most abundant CE component is loricrin (65-70%), while involucrin is a minor component (<5%). The other CE proteins are classified as small...
PMID 8809402. Steinert PM, Marekov LN (January 1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte...
small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes"...
PMID 8780679. Steinert PM, Marekov LN (January 1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte...
PMID 7525601. Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte...
"Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis...
PMID 8823304. Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte...
"Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis...
2000). "Requirement of an AP-1 site in the calcium response region of the involucrin promoter". The Journal of Biological Chemistry. 275 (31): 24080–8. doi:10...
PMID 8707850. Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte...
PMID 7869384. Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte...
region underlined in the conceptual translation was predicted to be an Involucrin repeat. The transmembrane region is 1674.2 daltons while the whole protein...
small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes"...
primary keratinocytes and downregulates differentiation markers such as involucrin, transglutaminase-1, and cytokeratin-10. The hormone 1,25-dihydroxyvitamin-D3...
PMID 9826750. Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte...
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