negative regulation of cytosolic calcium ion concentration
chemical synaptic transmission
stabilization of membrane potential
regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3777
16527
Ensembl
ENSG00000171303
ENSMUSG00000049265
UniProt
O14649
O35111
RefSeq (mRNA)
NM_002246
NM_010608
RefSeq (protein)
NP_002237
NP_034738
Location (UCSC)
Chr 2: 26.69 – 26.73 Mb
Chr 5: 30.75 – 30.78 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Potassium channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene.[5][6][7][8]
This gene encodes K2P3.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P3.1 is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000171303 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000049265 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M (Dec 1997). "TASK, a human background K+ channel to sense external pH variations near physiological pH". EMBO J. 16 (17): 5464–71. doi:10.1093/emboj/16.17.5464. PMC 1170177. PMID 9312005.
^Lesage F, Lazdunski M (Oct 1998). "Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23". Genomics. 51 (3): 478–9. doi:10.1006/geno.1998.5397. PMID 9721223.
^Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ab"Entrez Gene: KCNK3 potassium channel, subfamily K, member 3".
channel subfamily K member 3 is a protein that in humans is encoded by the KCNK3 gene. This gene encodes K2P3.1, one of the members of the superfamily of...
2012). "The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic...
has a varied pattern of expression. TASK 3 is coexpressed with TASK 1 (KCNK3) in the cerebellar granule cells, locus coeruleus, motor neurons, pontine...
part of the larger Voltage sensitive phosphatase family KCNK1; KCNK2; KCNK3; KCNK4; KCNK5; KCNK6; KCNK7; KCNK9; KCNK10; KCNK12; KCNK13; KCNK15; KCNK16;...
1998). "Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23". Genomics. 51 (3): 478–9. doi:10.1006/geno...
has been shown to interact with TRPV5, TRPV6, TASK-1, ASIC1a, CTSB, BAD, KCNK3, UBC and ANXA2. There is a specificity in the interaction between p11 and...