TRPV5 information

TRPV5
Identifiers
Aliases	TRPV5, CAT2, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5
External IDs	OMIM: 606679; MGI: 2429764; HomoloGene: 10520; GeneCards: TRPV5; OMA:TRPV5 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	142,933,746 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	41,657,703 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; human kidney; ; substantia nigra; ; blood; ; corpus callosum; ; hippocampus proper; ; primary visual cortex; ; temporal lobe; ; amygdala; ; duodenum;
	Top expressed in
	blastocyst; ; right kidney; ; morula; ; human kidney; ; vasculature; ; vasculature of organ; ; spinal cord; ; embryo; ; temporal lobe; ; amygdala;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion channel activity; protein binding; calmodulin binding; metal ion binding; calcium channel activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; apical plasma membrane;
Biological process	ion transport; protein tetramerization; calcium ion transport; transmembrane transport; regulation of urine volume; calcium ion homeostasis; calcium ion transmembrane transport; calcium ion import across plasma membrane; protein homotetramerization;
	Sources:Amigo / QuickGO
Orthologs
	56302
	194352
	ENSG00000274348; ENSG00000127412
	ENSMUSG00000036899
	Q9NQA5
	P69744
	NM_019841
	NM_001007572
	NP_062815
	NP_001007573
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily V member 5 is a calcium channel protein that in humans is encoded by the TRPV5 gene.^[5]^[6]^[7]

^ ^a ^b ^c ENSG00000127412 GRCh38: Ensembl release 89: ENSG00000274348, ENSG00000127412 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036899 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Müller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (August 2000). "Gene structure and chromosomal mapping of human epithelial calcium channel". Biochemical and Biophysical Research Communications. 275 (1): 47–52. doi:10.1006/bbrc.2000.3227. PMID 10944439.
^ Müller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, et al. (July 2000). "Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1)". Genomics. 67 (1): 48–53. doi:10.1006/geno.2000.6203. PMID 10945469.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[refGRCh38Ensembl-1] ENSG00000127412 GRCh38: Ensembl release 89: ENSG00000274348, ENSG00000127412 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036899 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10944439-5] Müller D, Hoenderop JG, Merkx GF, van Os CH, Bindels RJ (August 2000). "Gene structure and chromosomal mapping of human epithelial calcium channel". Biochemical and Biophysical Research Communications. 275 (1): 47–52. doi:10.1006/bbrc.2000.3227. PMID 10944439.

[pmid10945469-6] Müller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, et al. (July 2000). "Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1)". Genomics. 67 (1): 48–53. doi:10.1006/geno.2000.6203. PMID 10945469.

[pmid16382100-7] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

TRPV5 information

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