The epidermal differentiation complex (EDC) is a gene complex comprising over fifty genes encoding proteins involved in the terminal differentiation and cornification of keratinocytes, the primary cell type of the epidermis. In humans, the complex is located on a 1.9 Mbp stretch within chromosome 1q21.[1][2] The proteins encoded by EDC genes are closely related in terms of function, and evolutionarily they belong to three distinct gene families: the cornified envelope precursor family, the S100 protein family and the S100 fused type protein (SFTP) family.[3]
It has been hypothesized that the clustering of EDC genes occurred due to duplication events which were evolutionarily favored during the adaptation to terrestrial environments.[3][4] In sirenians, the main subtypes of EDC genes have been conserved or even duplicated, such as the duplicated late cornified envelope genes of dugongs. On the other hand, FLG genes of the SFTP family have become inactivated in sirenians, with the exception of manatees. Cetaceans have also lost function of FLG genes.[5] EDC proteins have been involved in a variety of skin disorders including ichthyosis vulgaris, atopic dermatitis and psoriasis.[6]
^Volz, Armin; Korge, Bernhard P.; Compton, John G.; Ziegler, Andreas; Steinert, Peter M.; Mischke, Dietmar (October 1993). "Physical Mapping of a Functional Cluster of Epidermal Differentiation Genes on Chromosome 1q21". Genomics. 18 (1): 92–99. doi:10.1006/geno.1993.1430. PMID 8276421.
^Mischke, Dietmar; Korge, Bernhard P.; Marenholz, Ingo; Volz, Armin; Ziegler, Andreas (May 1996). "Genes Encoding Structural Proteins of Epidermal Cornification and S100 Calcium-Binding Proteins Form a Gene Complex ("Epidermal Differentiation Complex") on Human Chromosome 1q21". Journal of Investigative Dermatology. 106 (5): 989–992. doi:10.1111/1523-1747.ep12338501. PMID 8618063.
^ abKypriotou, Magdalini; Huber, Marcel; Hohl, Daniel (September 2012). "The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family". Experimental Dermatology. 21 (9): 643–649. doi:10.1111/j.1600-0625.2012.01472.x. PMID 22507538.
^Backendorf, C; Hohl, D (October 1992). "A common origin for cornified envelope proteins?". Nature Genetics. 2 (2): 91. doi:10.1038/ng1092-91. PMID 1303269. S2CID 28646784.
^Steinbinder, Julia; Sachslehner, Attila Placido; Holthaus, Karin Brigit; Eckhart, Leopold (2024-04-23). "Comparative genomics of sirenians reveals evolution of filaggrin and caspase-14 upon adaptation of the epidermis to aquatic life". Scientific Reports. 14 (1): 9278. doi:10.1038/s41598-024-60099-2. ISSN 2045-2322. PMC 11039687. PMID 38653760.
^Hoffjan, S; Stemmler, S (September 2007). "On the role of the epidermal differentiation complex in ichthyosis vulgaris, atopic dermatitis and psoriasis". British Journal of Dermatology. 157 (3): 441–449. doi:10.1111/j.1365-2133.2007.07999.x. PMID 17573887. S2CID 9434345.
and 28 Related for: Epidermal differentiation complex information
The epidermaldifferentiationcomplex (EDC) is a gene complex comprising over fifty genes encoding proteins involved in the terminal differentiation and...
part of the S100 fused-type protein (SFTP) family within the epidermaldifferentiationcomplex on chromosome 1q21. In cetaceans and sirenians, the FLG family...
gene maps outside the epidermaldifferentiationcomplex (EDC), a cluster of three gene families involved in epidermaldifferentiation. Alternatively spliced...
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor...
skin, is a part of the epidermaldifferentiationcomplex, and potentially plays a role in epidermal cornification, and epidermal barrier function. C1orf68...
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has...
humans is encoded by the SPRR3 gene, which is found within the epidermaldifferentiationcomplex (EDC). GRCh38: Ensembl release 89: ENSG00000163209 – Ensembl...
Cell junctions or junctional complexes are a class of cellular structures consisting of multiprotein complexes that provide contact or adhesion between...
as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). HER2 is a member of the human epidermal growth factor receptor...
Koebnerisin (S100A7A) maps to the S100 gene cluster within the epidermaldifferentiationcomplex (EDC, chromosome 1q21) and reveals an unusual genomic organization...
function in epidermaldifferentiation independently of the NF-κB pathway. In the mouse, IKK-α is required for cell cycle exit and differentiation of the embryonic...
PglyrpIalpha and PglyrpIbeta are encoded in the epidermaldifferentiationcomplex and are expressed in epidermal and hematopoietic tissues". Genomics. 83 (6):...
PMID 12356720. Schellmann, Swen; Hulskamp, Martin (2004-09-01). "Epidermaldifferentiation: trichomes in Arabidopsis as a model system". The International...
Le Roux I, Dunne J, Watt FM (May 2000). "Stimulation of human epidermaldifferentiation by delta-notch signalling at the boundaries of stem-cell clusters"...
is known as the epidermaldifferentiationcomplex, since it harbors over fifty other genes involved in keratinocyte differentiation. Gene coding sequence...
PglyrpIalpha and PglyrpIbeta are encoded in the epidermaldifferentiationcomplex and are expressed in epidermal and hematopoietic tissues". Genomics. 83 (6):...
intermediate filaments, which are tough and form strong unmineralized epidermal appendages found in reptiles, birds, amphibians, and mammals. Excessive...
a variety of conserved elements including immunoglobulin (Ig)-like or epidermal growth factor (EGF)-like domains, fibronectin type III repeats, or cysteine-rich...
tumor growth suppressors, agents that regulate cell proliferation and differentiation. Prognosis is highly variable and depends on the symptoms, but life...
domain. hJTB is located in a gene-rich region at 1q21, called epidermaldifferentiationcomplex (EDC). JTB has also been implicated in prostatic carcinomas...
Ziegler A, Mischke D (Mar 2001). "Identification of human epidermaldifferentiationcomplex (EDC)-encoded genes by subtractive hybridization of entire...
in dogs under three years of age. Epidermal invasion by cells of histiocytoma frequently occurs and intra-epidermal nests of histiocytes resemble Pautrier's...
participate in a variety of cellular signaling: examples include regulating differentiation, proliferation, and programmed cell death (PCD) of cells. The word...
receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich...
meristem and its presence prevents the differentiation of the stem cells. CLV1 acts to promote cellular differentiation by repressing WUS activity outside...
PglyrpIalpha and PglyrpIbeta are encoded in the epidermaldifferentiationcomplex and are expressed in epidermal and hematopoietic tissues". Genomics. 83 (6):...
Global Information