TRPV6 is a membrane calcium (Ca2+) channel protein which is particularly involved in the first step in Ca2+absorption in the intestine. Transient Receptor...
heterotetramers and is activated by a low internal calcium level. Both TRPV5 and TRPV6 are expressed in kidney and intestinal epithelial cells. TRPV5 is mainly...
cell's brush border membrane. The TRPV6 channel was proposed to be the major player in intestinal Ca2+ uptake. However, Trpv6 KO mice did not display significant...
factor that modulates the gene expression of transport proteins (such as TRPV6 and calbindin), which are involved in calcium absorption in the intestine...
sea anemone (Stoichactis helianthus) Clinical development SOR-C13 Cancer TRPV6 N. short-tailed shrew (Blarina brevicauda) Clinical development HsTX1 [R14A]...
and conformation. In TRPV6, a number of putative regulatory phosphorylation sites map to the base of this third finger. The TRPV6-ARD does not assemble...
the interaction with p11. Some of these proteins include Nav1.8, TRPV5, TRPV6, TASK-1, and ASIC1a. Nav1.8 is a tetrodotoxin-resistant sodium channel that...
expression of TRP proteins often leads to tumorigenesis, as reported for TRPV1, TRPV6, TRPC1, TRPC6, TRPM4, TRPM5, and TRPM8. TRPV1 and TRPV2 have been implicated...
leads to tumorigenesis, clearly seen in TRPM1. Particularly high levels of TRPV6 in prostate cancer have been noted. Such observations could be helpful in...
enterocytes from the apical side, where entry is regulated by the calcium channel TRPV6, to the basolateral side, where calcium pumps such as PMCA1 utilize intracellular...
nerve impulses by inhibiting sodium channels, soricidin also inhibits the TRPV6 calcium channel, which is over-expressed in many epithelial-cell cancers;...
higher than other PHA2 types. Aldosterone concentrations are often normal. TRPV6 may be involved. PHA2C 614492 WNK1 Autosomal dominant 15+ with a mean age...
calcium channel, with an IC50 of 177 nM and high selectivity for TRPV5 over TRPV6 and the other subtypes of TRPV. It is the first selective inhibitor to be...
(later identified as the vitamin D regulated epithelial calcium channel, TRPV6)." Wasserman was a member of the editorial boards of the Proceedings of...
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