Not to be confused with the cells of the islets of Langerhans in the pancreas, or Langhans giant cell.
Langerhans cell
Section of skin showing large numbers of Langerhans cells in the epidermis. (M. ulcerans infection, S100 immunoperoxidase stain.)
Details
System
Immune system
Location
Skin and mucosa
Function
Dendritic cell
Identifiers
MeSH
D007801
FMA
63072
Anatomical terms of microanatomy
[edit on Wikidata]
The representation of Langerhans cells in the Cell Ontology. A portion of the Cell Ontology is shown with ovals corresponding to cell types defined in the ontology and arrows corresponding to relations between those cell types. Langerhans cell is represented by a yellow oval; blue arrows correspond to is_a relations, and orange arrows correspond to develops_from relations. Only a subset of Langerhans cell parent types are included in the figure.[1]
A Langerhans cell (LC) is a tissue-resident macrophage of the skin[2] once thought to be a resident dendritic cell.[3] These cells contain organelles called Birbeck granules. They are present in all layers of the epidermis and are most prominent in the stratum spinosum.[4] They also occur in the papillary dermis, particularly around blood vessels,[4] as well as in the mucosa of the mouth, foreskin, and vaginal epithelium.[5] They can be found in other tissues, such as lymph nodes, particularly in association with the condition Langerhans cell histiocytosis (LCH).
^Masci, Anna; Arighi, Cecilia N; Diehl, Alexander D; Lieberman, Anne E; Mungall, Chris; Scheuermann, Richard H; Smith, Barry; Cowell, Lindsay G (2009). "An improved ontological representation of dendritic cells as a paradigm for all cell types". BMC Bioinformatics. 10: 70. doi:10.1186/1471-2105-10-70. PMC 2662812. PMID 19243617.
^Doebel, T.; Voisin, B.; Nagao, K. (2017). "Langerhans Cells – The Macrophage in Dendritic Cell Clothing". Trends in Immunology. 38 (11): 817–828. doi:10.1016/j.it.2017.06.008. PMID 28720426.
^"MeSH Browser".
^ abYoung, Barbara; Heath, John W. (2000). Wheater's Functional Histology (4th ed.). Churchill Livingstone. p. 162. ISBN 0-443-05612-9.
^Cite error: The named reference pmid7558138 was invoked but never defined (see the help page).
A Langerhanscell (LC) is a tissue-resident macrophage of the skin once thought to be a resident dendritic cell. These cells contain organelles called...
Langerhanscell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhanscells, abnormal cells deriving from bone marrow and capable of migrating...
pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German...
were first described by Paul Langerhans (hence Langerhanscells) in the late nineteenth century. The term dendritic cells was coined in 1973 by Ralph M...
Langerhanscell sarcoma (LCS) is a rare form of malignant histiocytosis. It should not be confused with Langerhanscell histiocytosis, which is cytologically...
Chronic multifocal Langerhanscell histiocytosis, previously known as Hand–Schüller–Christian disease, is a type of Langerhanscell histiocytosis (LCH)...
rheumatoid nodules). Some sources consider Langerhanscell derivatives to be histiocytes. The Langerhanscell histiocytosis embeds this interpretation into...
found in Langerhanscells. Although part of normal Langerhanscell histology, they also provide a mechanism to differentiate Langerhanscell histiocytoses...
the islets of Langerhans. Islets of Langerhans – Pancreatic cells which include insulin-producing cells. Langerhans discovered these cells during his studies...
other cell types such as melanocytes and Langerhanscells. Keratinocytes form tight junctions with the nerves of the skin and hold the Langerhanscells and...
Langerhans may refer to: Paul Langerhans (1847–1888), German pathologist and biologist Langerhanscells, dendritic cells abundant in the epidermis Islets...
Islets of Langerhans were first discussed by Paul Langerhans in his medical thesis in 1869. This same year, Laguesse named them after Langerhans. At first...
from haematopoietic stem cells. In a healthy adult human, roughly ten billion (1010) to a hundred billion (1011) new blood cells are produced per day, in...
Beta cells (β-cells) are specialized endocrine cells located within the pancreatic islets of Langerhans responsible for the production and release of insulin...
Macrophages Kupffer cells - in the liver Langerhanscells - in the skin and mucosa (*these are a form of dendritic cells) Alveolar macrophages - in the lungs...
There is estimated to be about 30 trillion (3×1013) human cells in the adult human body, varying from about 20 to 40 trillion depending on the sex, age...
antigens. Langerhans' cells are particular type of dendritic cells present in non lymphoid tissues together with interstitial cells. When these cells (in an...
in the 264. position leads to a loss of Birbeck granules. Paul LangerhansLangerhanscell GRCh38: Ensembl release 89: ENSG00000116031 – Ensembl, May 2017...
characterized by abnormal proliferation of Langerhanscells (LCs). LCs are antigen-presenting cells derived from dendritic cells. In humans, eosinophilic granulomas...
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