N-acylphosphatidylethanolamine-specific phospholipase D activity
protein binding
catalytic activity
phosphatidylinositol binding
hydrolase activity
Cellular component
cytoplasm
late endosome membrane
Golgi membrane
endocytic vesicle
lysosomal membrane
apical plasma membrane
endoplasmic reticulum
perinuclear region of cytoplasm
endosome
endoplasmic reticulum membrane
membrane
Golgi apparatus
plasma membrane
specific granule membrane
tertiary granule membrane
cholinergic synapse
Biological process
regulation of microvillus assembly
lipid metabolism
cell motility
small GTPase mediated signal transduction
lipid catabolic process
chemotaxis
Ras protein signal transduction
neutrophil degranulation
phosphatidic acid biosynthetic process
inositol lipid-mediated signaling
regulation of synaptic vesicle cycle
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5337
18805
Ensembl
ENSG00000075651
ENSMUSG00000027695
UniProt
Q13393
Q9Z280
RefSeq (mRNA)
NM_001130081 NM_002662
NM_001164056 NM_008875 NM_001368667
RefSeq (protein)
NP_001123553 NP_002653
n/a
Location (UCSC)
Chr 3: 171.6 – 171.81 Mb
Chr 3: 27.99 – 28.19 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Phospholipase D1 (PLD1) is an enzyme that in humans is encoded by the PLD1 gene,[5][6] though analogues are found in plants, fungi, prokaryotes, and even viruses.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000075651 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027695 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Park SH, Chun YH, Ryu SH, Suh PG, Kim H (February 1999). "Assignment of human PLD1 to human chromosome band 3q26 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 82 (3–4): 224. doi:10.1159/000015105. PMID 9858822. S2CID 46791637.
^Hammond SM, Altshuller YM, Sung TC, Rudge SA, Rose K, Engebrecht J, et al. (December 1995). "Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family". The Journal of Biological Chemistry. 270 (50): 29640–3. doi:10.1074/jbc.270.50.29640. PMID 8530346.
^Selvy PE, Lavieri RR, Lindsley CW, Brown HA (October 2011). "Phospholipase D: enzymology, functionality, and chemical modulation". Chemical Reviews. 111 (10): 6064–119. doi:10.1021/cr200296t. PMC 3233269. PMID 21936578.
PhospholipaseD1 (PLD1) is an enzyme that in humans is encoded by the PLD1 gene, though analogues are found in plants, fungi, prokaryotes, and even viruses...
Phospholipase D (EC 3.1.4.4, lipophosphodiesterase II, lecithinase D, choline phosphatase, PLD; systematic name phosphatidylcholine phosphatidohydrolase)...
Dopamine receptor D1, also known as DRD1. It is one of the two types of D1-like receptor family — receptors D1 and D5. It is a protein that in humans is...
"Structure and expression of the human glycosylphosphatidylinositol phospholipaseD1 (GPLD1) gene". Biochimica et Biophysica Acta (BBA) - Gene Structure...
Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene. Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis...
"RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipaseD1". Biochemical and Biophysical Research Communications. 235 (3): 854–9...
been found to interact with effectors upstream in the mTOR pathway. PhospholipaseD1 (PLD1) is upstream in the mTOR pathway and serves as a positive effector...
through direct interactions. There is evidence that D1 receptor agonism regulates phospholipase C independent of cAMP, however implications and mechanisms...
and PtdCho between membranes as well as the inhibition of phospholipaseD1 and phospholipase B1, which convert PtdCho to phosphatidic acid and choline...
PMID 9653114. Kim JH, Lee SD, Han JM, et al. (1998). "Activation of phospholipaseD1 by direct interaction with ADP-ribosylation factor 1 and RalA". FEBS...
stabilization events. Amphiphysin has been shown to interact with DNM1, PhospholipaseD1, CDK5R1, PLD2, CABIN1 and SH3GL2. AP180 Epsin GRCh38: Ensembl release...
Chneiweiss H, Kanaho Y, Frohman MA (2001). "Regulation of expression of phospholipaseD1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol...
T-tubules seen in heart failure. BIN1 has been shown to interact with PhospholipaseD1, SNX4 and PLD2. GRCh38: Ensembl release 89: ENSG00000136717 – Ensembl...
PEA15 has been shown to interact with: Caspase 8, FADD, and MAPK1, PhospholipaseD1, and RPS6KA3. GRCh38: Ensembl release 89: ENSG00000162734 – Ensembl...
alpha's ability to translocate to the perinuclear region and activate phospholipaseD1". Biochemical and Biophysical Research Communications. 333 (3): 750–3...
GTP-bound state include the microtubule-associated protein kinectin, PhospholipaseD1 and the MAP Kinase activator MLK3. RhoG has been shown to interact...
Phospholipase C epsilon 1 (PLCE1) is an enzyme that in humans is encoded by the PLCE1 gene. This gene encodes a phospholipase enzyme (PLCE1) that catalyzes...
G-protein receptor can affect the function of adenylate cyclase or phospholipase C, an agonist of the receptor will upregulate the effects on the downstream...
Protectin D1 also known as neuroprotectin D1 (when it acts in the nervous system) and abbreviated most commonly as PD1 or NPD1 is a member of the class...
pathway of helper T cells. The J.gamma1 subline contains no detectable phospholipase C-gamma1 (PLC-γ1) protein and therefore has profound defects in T cell...
humans is encoded by the DRD5 gene. It belongs to the D1-like receptor family along with the D1 receptor subtype. D5 receptor is a subtype of the dopamine...
"Membrane-mediated actions of 1,25-dihydroxy vitamin D3: a review of the roles of phospholipase A2 activating protein and Ca(2+)/calmodulin-dependent protein kinase...
kDa calcium-independent phospholipase A2, also known as 85/88 kDa calcium-independent phospholipase A2, Group VI phospholipase A2, Intracellular membrane-associated...
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