PKC alpha information

PRKCA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ELI, 3IW4, 4DNL, 4RA4
Identifiers
Aliases	PRKCA, AAG6, PKC-alpha, PKCA, PRKACA, protein kinase C alpha, PKCI+/-, PKCalpha
External IDs	OMIM: 176960; MGI: 97595; HomoloGene: 55679; GeneCards: PRKCA; OMA:PRKCA - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	66,810,743 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	108,234,754 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; external globus pallidus; ; trigeminal ganglion; ; dorsal motor nucleus of vagus nerve; ; pars reticulata; ; entorhinal cortex; ; postcentral gyrus; ; Brodmann area 23; ; Pars compacta; ; inferior olivary nucleus;
	Top expressed in
	substantia nigra; ; Paneth cell; ; subiculum; ; ventral tegmental area; ; Region I of hippocampus proper; ; olfactory tubercle; ; nucleus accumbens; ; globus pallidus; ; triceps brachii muscle; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein kinase C activity; zinc ion binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; enzyme binding; histone kinase activity (H3-T6 specific); ATP binding; calcium-dependent protein kinase C activity; integrin binding;
Cellular component	cytoplasm; cytosol; mitochondrial membranes; membrane; plasma membrane; nucleoplasm; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; extracellular exosome; nucleus; alphav-beta3 integrin-PKCalpha complex;
Biological process	apoptotic process; negative regulation of adenylate cyclase activity; intracellular signal transduction; response to interleukin-1; positive regulation of endothelial cell proliferation; regulation of mRNA stability; regulation of insulin secretion; phosphorylation; positive regulation of cell migration; negative regulation of glial cell apoptotic process; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; activation of adenylate cyclase activity; positive regulation of angiogenesis; positive regulation of cardiac muscle hypertrophy; positive regulation of endothelial cell migration; platelet activation; positive regulation of lipopolysaccharide-mediated signaling pathway; protein phosphorylation; mitotic nuclear membrane disassembly; desmosome assembly; cell adhesion; peptidyl-serine phosphorylation; angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of ERK1 and ERK2 cascade; apoptotic signaling pathway; positive regulation of dense core granule biogenesis; regulation of platelet aggregation; positive regulation of cell adhesion; axon guidance; ERBB2 signaling pathway; peptidyl-threonine phosphorylation; positive regulation of bone resorption; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5578
	18750
	ENSG00000154229
	ENSMUSG00000050965
	P17252
	P20444
	NM_002737
	NM_011101
	NP_002728
	NP_035231
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154229 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050965 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154229 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050965 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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