ARIH1 information

ARIH1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WD2, 2M9Y, 4KBL, 4KC9
Identifiers
Aliases	ARIH1, ARI, HARI, HHARI, UBCH7BP, ariadne RBR E3 ubiquitin protein ligase 1
External IDs	OMIM: 605624; MGI: 1344363; HomoloGene: 111871; GeneCards: ARIH1; OMA:ARIH1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	72,602,987 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	59,393,901 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sural nerve; ; ganglionic eminence; ; stromal cell of endometrium; ; Achilles tendon; ; gastrocnemius muscle; ; popliteal artery; ; skin of abdomen; ; internal globus pallidus; ; human penis;
	Top expressed in
	secondary oocyte; ; seminiferous tubule; ; extensor digitorum longus muscle; ; spermatid; ; plantaris muscle; ; triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; ankle; ; digastric muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin-like protein transferase activity; protein binding; metal ion binding; ubiquitin protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; transferase activity; ubiquitin conjugating enzyme binding; zinc ion binding;
Cellular component	cytoplasm; ubiquitin ligase complex; cytosol; nucleus; Cajal body; nuclear body; SCF ubiquitin ligase complex; Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; Cul4A-RING E3 ubiquitin ligase complex; Lewy body;
Biological process	protein polyubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	25820
	23806
	ENSG00000166233
	ENSMUSG00000025234
	Q9Y4X5
	Q9Z1K5
	NM_005744
	NM_019927
	NP_005735
	NP_064311
	Wikidata
View/Edit Human	View/Edit Mouse

Protein ariadne-1 homolog is a protein that in humans is encoded by the ARIH1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166233 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025234 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (November 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.
^ "Entrez Gene: ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166233 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025234 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10521492-5] Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (November 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.

[entrez-6] "Entrez Gene: ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)".

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