Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopamine receptors activate different effectors through not only G-protein coupling, but also signaling through different protein (dopamine receptor-interacting proteins) interactions.[1] The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors.
Dopamine receptors are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders.[2] Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors.
^Rondou P, Haegeman G, Van Craenenbroeck K (June 2010). "The dopamine D4 receptor: biochemical and signalling properties". Cellular and Molecular Life Sciences. 67 (12): 1971–86. doi:10.1007/s00018-010-0293-y. PMID 20165900. S2CID 21432517.
^Girault JA, Greengard P (2004). "The neurobiology of dopamine signaling". Arch. Neurol. 61 (5): 641–4. doi:10.1001/archneur.61.5.641. PMID 15148138.
Dopaminereceptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). Dopaminereceptors activate...
Dopaminereceptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested...
The dopaminereceptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5. The structure of DRD4...
Dopaminereceptor D1, also known as DRD1. It is one of the two types of D1-like receptor family — receptors D1 and D5. It is a protein that in humans...
A dopamine agonist (DA) is a compound that activates dopaminereceptors. There are two families of dopaminereceptors, D1-like and D2-like. They are all...
cue-motivated behavior via CB1 receptor activation in the ventral tegmentum, and thereby modulates cue-evoked dopamine transients during the pursuit of...
Dopaminereceptor D3 is a protein that in humans is encoded by the DRD3 gene. This gene encodes the D3 subtype of the dopaminereceptor. The D3 subtype...
dopamine antagonist, also known as an anti-dopaminergic and a dopaminereceptor antagonist (DRA), is a type of drug which blocks dopaminereceptors by...
Dopaminereceptor D5, also known as D1BR, is a protein that in humans is encoded by the DRD5 gene. It belongs to the D1-like receptor family along with...
large number of antipsychotics have dopamine-receptor antagonistic effects. The theory, however, does not posit dopamine overabundance as a complete explanation...
by blocking dopaminereceptors. When endogenous dopamine levels are low, cariprazine acts more as an agonist, increasing dopaminereceptor activity. In...
and dopaminereceptors can be classified as dopaminergic, and neurons that synthesize or contain dopamine and synapses with dopaminereceptors in them...
mixed agonist and antagonist of dopamine, serotonin, and adrenergic receptors. Activation of specific dopaminereceptors is thought to be responsible for...
other dopamine agonists, such as pramipexole, may also trigger the condition. The underlying mechanism involves blockage of dopaminereceptors. Diagnosis...
addictive drugs — cause a dopamine spike of 350% and 1200% respectively[citation needed]. In addition, dopaminereceptors themselves — the cells in the...
ergoline-based dopaminereceptor agonist used in some countries for the treatment of Parkinson's disease. Parkinson's disease is associated with reduced dopamine activity...
express dopamine D1 receptors. The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation...
D2-type (i.e., DRD2, DRD3, and DRD4) dopaminereceptors. A subpopulation of MSNs contain both D1-type and D2-type receptors, with approximately 40% of striatal...
dyskinesia occurs in some people as a result of long-term use of dopamine-receptor-blocking medications such as antipsychotics and metoclopramide. These...
tyrosine hydroxylase and D2 dopaminereceptors. The latter was thus demonstrated to be an autoreceptor on cells that release dopamine. TAAR1 is a presynaptic...
D4 dopaminereceptors, pramipexole may directly stimulate the underfunctioning dopaminereceptors in the striatum, thereby restoring the dopamine signals...
the ventral tegmentum or substantia nigra as examples. It acts on dopaminereceptors. Parkinson's disease is at least in part related to dropping out of...
receptor and heightens the receptor's activity; the receptor antagonists work by binding to the receptor and blocking the activation of the receptor by...
of the 5-HT2A receptor are sometimes used as atypical antipsychotics (contrast with typical antipsychotics, which are purely dopamine antagonists). They...
significant role in learning, motivation, reward, memory and movement. Dopaminereceptor subtypes, D1 and D2 have been shown to have complementary functions...
more slowly from the synaptic cleft and continues to activate the dopaminereceptors on the target cell. Until the early 20th century, scientists assumed...
Petrocellis L, Di Marzo V (November 2000). "N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation...
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