CDC42 information

CDC42
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YDH, 1A4R, 1AJE, 1AM4, 1AN0, 1CEE, 1CF4, 1DOA, 1E0A, 1EES, 1GRN, 1GZS, 1KI1, 1KZ7, 1KZG, 1NF3, 2ASE, 2DFK, 2KB0, 2NGR, 2ODB, 2QRZ, 2WM9, 2WMN, 2WMO, 3GCG, 3QBV, 3VHL, 4DID, 4ITR, 4JS0, 4YC7, 5FI1
Identifiers
Aliases	CDC42, CDC42Hs, G25K, TKS, cell division cycle 42
External IDs	OMIM: 116952; MGI: 106211; HomoloGene: 123986; GeneCards: CDC42; OMA:CDC42 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	22,101,360 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	137,357,720 bp
RNA expression pattern
	Top expressed in
	monocyte; ; islet of Langerhans; ; rectum; ; ganglionic eminence; ; gallbladder; ; epithelium of colon; ; smooth muscle tissue; ; olfactory zone of nasal mucosa; ; granulocyte; ; ventricular zone;
	Top expressed in
	ascending aorta; ; aortic valve; ; Epithelium of choroid plexus; ; endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; medullary collecting duct; ; renal corpuscle; ; molar; ; vestibular sensory epithelium; ; dermis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	Rho GDP-dissociation inhibitor binding; ubiquitin protein ligase activity; apolipoprotein A-I receptor binding; GTP-dependent protein binding; GTPase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; thioesterase binding; protein kinase binding; nucleotide binding; GTP binding; identical protein binding; protein serine/threonine kinase activity; GBD domain binding;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; focal adhesion; microtubule organizing center; spindle midzone; neuron projection; storage vacuole; cytoskeleton; cell projection; myelin sheath; extracellular exosome; filopodium; plasma membrane; spindle; apical part of cell; secretory granule; neuronal cell body; cytoplasmic ribonucleoprotein granule; mitotic spindle; leading edge membrane; cell periphery; endoplasmic reticulum membrane; Golgi membrane; midbody; centrosome; cell cortex; Golgi transport complex; protein-containing complex; dendritic spine;
Biological process	cardiac conduction system development; positive regulation of protein phosphorylation; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of muscle cell differentiation; nuclear migration; keratinization; positive regulation of JNK cascade; establishment of Golgi localization; actin filament bundle assembly; positive regulation of neuron apoptotic process; vascular endothelial growth factor receptor signaling pathway; hair follicle morphogenesis; heart contraction; regulation of protein stability; neuron fate determination; substantia nigra development; Fc-gamma receptor signaling pathway involved in phagocytosis; actin filament organization; negative regulation of protein-containing complex assembly; epithelial-mesenchymal cell signaling; actin filament branching; negative regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; establishment or maintenance of cell polarity; positive regulation of cell growth; regulation of protein metabolic process; establishment or maintenance of apical/basal cell polarity; regulation of protein kinase activity; regulation of attachment of spindle microtubules to kinetochore; regulation of small GTPase mediated signal transduction; positive regulation of hair follicle cell proliferation; positive regulation of MAPK cascade; regulation of mitotic nuclear division; hair follicle placode formation; positive regulation of intracellular protein transport; cell differentiation; positive regulation of epithelial cell proliferation involved in lung morphogenesis; regulation of protein heterodimerization activity; Golgi organization; positive regulation of synapse structural plasticity; multicellular organism growth; epidermis morphogenesis; nucleus localization; epithelial cell-cell adhesion; sprouting angiogenesis; nervous system development; macrophage differentiation; dendritic cell migration; positive regulation of cytokinesis; positive regulation of DNA replication; Wnt signaling pathway, planar cell polarity pathway; keratinocyte development; regulation of protein catabolic process; canonical Wnt signaling pathway; adherens junction organization; organelle transport along microtubule; actin cytoskeleton organization; regulation of filopodium assembly; endocytosis; ephrin receptor signaling pathway; filopodium assembly; T cell costimulation; blood coagulation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of gene expression; positive regulation of pseudopodium assembly; submandibular salivary gland formation; viral RNA genome replication; small GTPase mediated signal transduction; protein ubiquitination; positive regulation of catalytic activity; protein phosphorylation; phagocytosis, engulfment; integrin-mediated signaling pathway; Rho protein signal transduction; regulation of cell shape; regulation of lamellipodium assembly; positive regulation of lamellipodium assembly; cell projection assembly; Cdc42 protein signal transduction; regulation of actin cytoskeleton organization; cell junction assembly; interleukin-12-mediated signaling pathway; neuropilin signaling pathway; establishment of epithelial cell apical/basal polarity; positive regulation of filopodium assembly; regulation of stress fiber assembly; positive regulation of stress fiber assembly; dendritic spine morphogenesis; modification of synaptic structure; positive regulation of actin cytoskeleton reorganization;
	Sources:Amigo / QuickGO
Orthologs
	998
	12540
	ENSG00000070831
	ENSMUSG00000006699
	P60953
	P60766
	NM_044472; NM_001039802; NM_001791
	NM_001243769; NM_009861
	NP_001034891; NP_001782; NP_426359
	NP_001230698; NP_033991
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division control protein 42 homolog (Cdc42 or CDC42) is a protein that in humans is encoded by the CDC42 gene. Cdc42 is involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division,^[5]^[6] and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070831 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006699 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adams AE, Johnson DI, Longnecker RM, Sloat BF, Pringle JR (July 1990). "CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae". The Journal of Cell Biology. 111 (1): 131–142. doi:10.1083/jcb.111.1.131. PMC 2116161. PMID 2195038.
^ Johnson DI, Pringle JR (July 1990). "Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity". The Journal of Cell Biology. 111 (1): 143–152. doi:10.1083/jcb.111.1.143. PMC 2116164. PMID 2164028.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000070831 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006699 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Adams AE, Johnson DI, Longnecker RM, Sloat BF, Pringle JR (July 1990). "CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae". The Journal of Cell Biology. 111 (1): 131–142. doi:10.1083/jcb.111.1.131. PMC 2116161. PMID 2195038.

[6] Johnson DI, Pringle JR (July 1990). "Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity". The Journal of Cell Biology. 111 (1): 143–152. doi:10.1083/jcb.111.1.143. PMC 2116164. PMID 2164028.

CDC42 information

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CDC42EP1

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