A 3D depiction of Sec14p, with 2 molecules of octyl glucoside (in cyan) as a remnant of crystallization
Identifiers
Organism
Saccharomyces cerevisiae
Symbol
SEC14
Entrez
855103
PDB
1AUA
RefSeq (mRNA)
NM_001182578.1
RefSeq (Prot)
NP_013796
UniProt
P24280
Other data
Chromosome
XIII: 0.42 - 0.43 Mb
Search for
Structures
Swiss-model
Domains
InterPro
Sec14 is a cytosolic protein found in yeast (Saccharomyces cerevisiae) which plays a role in the regulation of several cellular functions, specifically those related to intracellular transport. Encoded by the Sec14 gene, Sec14p may transport phosphatidylinositol and phosphatidylcholine produced in the endoplasmic reticulum and the Golgi body to other cellular membranes. Additionally, Sec14p potentially plays a role in the localization of lipid raft proteins. Sec14p is an essential gene in yeast, and is homologous in function to phosphatidylinositol transfer protein in mammals. A conditional mutant with non-functional Sec14p presents with Berkeley bodies and deficiencies in protein secretion.
Sec14 is a cytosolic protein found in yeast (Saccharomyces cerevisiae) which plays a role in the regulation of several cellular functions, specifically...
SEC14-like protein 1 is a protein that in humans is encoded by the SEC14L1 gene. The protein encoded by this gene belongs to the SEC14 cytosolic factor...
SEC14 and spectrin domains 1, also known as SEC14 domain and spectrin repeat-containing protein 1 and Solo, is a protein that in humans is encoded by...
Saccharomyces cerevisiae, with a secretory mutation in the genes sec7 and sec14. The function of the organelle lies in the CTV (cytoplasm to vacuole targeting)...
SEC14L2 is a gene that, in humans, encodes the protein SEC14-like protein 2. This gene encodes a cytosolic protein which belongs to a family of lipid-binding...
GRD, neurofibromin also contains a Sec14 homology-like region as well as a pleckstrin homology-like (PH) domain. Sec14 domains are defined by a lipid binding...
interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). TRPC4 and TRPC5...
M313099200. PMID 14701795. Ueda S, Kataoka T, Satoh T (Aug 2004). "Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family...
contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and...
Global Information