dentate gyrus of hippocampal formation granule cell
skeletal muscle tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
phospholipase D activity
N-acylphosphatidylethanolamine-specific phospholipase D activity
protein binding
catalytic activity
phosphatidylinositol binding
hydrolase activity
Cellular component
Golgi apparatus
endoplasmic reticulum membrane
membrane
plasma membrane
presynapse
Biological process
Fc-gamma receptor signaling pathway involved in phagocytosis
lipid metabolism
cell motility
small GTPase mediated signal transduction
lipid catabolic process
synaptic vesicle recycling
cytoskeleton organization
phosphatidic acid biosynthetic process
inositol lipid-mediated signaling
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5338
18806
Ensembl
ENSG00000129219
ENSMUSG00000020828
UniProt
O14939
P97813
RefSeq (mRNA)
NM_001243108 NM_002663
NM_008876 NM_001302475 NM_001302476 NM_001361935
RefSeq (protein)
NP_001230037 NP_002654
NP_001289404 NP_001289405 NP_032902 NP_001348864
Location (UCSC)
Chr 17: 4.81 – 4.82 Mb
Chr 11: 70.43 – 70.45 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000129219 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020828 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Park SH, Ryu SH, Suh PG, Kim H (February 1999). "Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 82 (3–4): 225. doi:10.1159/000015106. PMID 9858823. S2CID 46805227.
^Lopez I, Arnold RS, Lambeth JD (May 1998). "Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2". The Journal of Biological Chemistry. 273 (21): 12846–52. doi:10.1074/jbc.273.21.12846. PMID 9582313.
Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene. Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis...
125 kDa. Mammalian cells encode two isoforms of phospholipase D: PLD1 and PLD2. Phospholipase D is an important player in many physiological processes,...
phosphatidylinositol 4,5-bisphosphate (PIP2). PLD2 has a PIP2 binding domain. When PIP2 concentration in the membrane increases, PLD2 leaves the GM1 domains and associates...
Phospholipase D2 (PLD2) binds PIP2 and localizes with lipid rafts. Increases in cholesterol overcome PIP2 binding and sequester PLD2 into GM1 lipid rafts...
phosphatidylinositol 4,5-bisphosphate (PIP2). PLD2 has a PIP2 binding domain. When PIP2 concentration in the membrane increases, PLD2 leaves the cholesterol-dependent...
domains for activators, inhibitors, and catalysis, which it shares with PLD2. Domains for both activation and inhibition are referred to as the phox homology...
Club1 Seasons Debut Last Season Pld2 W D L Goals Points3 Best Result Dinamo Minsk 33 1992 — 939 560 202 177 1701–794 1882 1st (1992, 1992–93, 1993–94,...
"GlycolysisGluconeogenesis_WP534". Aldolase A has been shown to interact with: PLD2, actin, GLUT4, phospholipase D2, light chain 8 of dynein, erythrocyte anion...
D family, however, it has no known catalytic function similar to PLD1 or PLD2. PLD3 serves as a ssDNA 5' exonuclease in antigen presenting cells. PLD3...
5417.1161. PMID 10325225. Ha SH, Kim DH, Kim IS, et al. (December 2006). "PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals"...
D2 (PLD2) is anesthetic sensitive and activates the potassium channel TREK-1 through a membrane mediated mechanism. The anesthetics displaced PLD2 from...
Amphiphysin has been shown to interact with DNM1, Phospholipase D1, CDK5R1, PLD2, CABIN1 and SH3GL2. AP180 Epsin GRCh38: Ensembl release 89: ENSG00000078053...
Hippocalcin takes part in the following processes: Activation of PLD1 and PLD2 expression Inhibition of apoptosis MAP kinase signalling Involved in long...
type B, PDGFRB, PDGFRA, PTGS2, TRAF2, estrogen receptor alpha, caveolin 2, PLD2, Bruton's tyrosine kinase, and SCP2. All these interactions are through a...
activate TREK-1 through the enzyme phospholipase D2 (PLD2). Prior to the addition of anesthetic, PLD2 associates with GM-1 lipid rafts. After anesthetic...
failure. BIN1 has been shown to interact with Phospholipase D1, SNX4 and PLD2. GRCh38: Ensembl release 89: ENSG00000136717 – Ensembl, May 2017 GRCm38:...
inhibition of ARF1. ARF1 has been shown to interact with: CHRM3, COPB1, GGA3, and PLD2. GRCh38: Ensembl release 89: ENSG00000143761 – Ensembl, May 2017 GRCm38:...
Kim JH, Lee MN, Lee HJ, Kim JH, Jang SK, Suh PG, Ryu SH (December 2006). "PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals"...
generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity". EMBO J. 19 (20): 5440–9. doi:10.1093/emboj/19.20.5440. PMC 314009...
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