Phenprobamate information

Phenprobamate
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M03BA01 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances);
Pharmacokinetic data
Elimination half-life	5–8 hours
Identifiers
	IUPAC name 3-Phenylpropylcarbamate;
CAS Number	673-31-4 ;
PubChem CID	4770;
ChemSpider	4606 ;
UNII	UJZ473TPS0;
KEGG	D01824 ;
ChEMBL	ChEMBL1079576 ;
CompTox Dashboard (EPA)	DTXSID2046464 ;
ECHA InfoCard	100.010.552
Chemical and physical data
Formula	C10H13NO2
Molar mass	179.219 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCCCc1ccccc1)N;
	InChI InChI=1S/C10H13NO2/c11-10(12)13-8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H2,11,12) ; Key:CAMYKONBWHRPDD-UHFFFAOYSA-N ;
	(what is this?) (verify)

Phenprobamate (Gamaquil, Isotonil, Actozine) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects.^[2]^{[unreliable source?]} Overdose is similar to barbiturates. Its mechanism of action is probably similar to meprobamate. Phenprobamate has been used in humans as an anxiolytic, and is still sometimes used in general anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some European countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolized by oxidative degradation of the carbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.^{[citation needed]}

Doses range from 400 to 800 mg, up to 3 times a day.^[3]

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Demir B, Demir Y, Aksoy I, Kilic OH, Gucyetmez V, Savas HA (June 2015). "Phenprobamate dependence: a case report". Addictive Behaviors. 45: 232–3. doi:10.1016/j.addbeh.2015.01.037. PMID 25727392.
^ "(meprobamate) dosing, indications, interactions, adverse effects, and more". Medscape. WebMD LLC. Retrieved 21 March 2024.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[pmid25727392-2] Demir B, Demir Y, Aksoy I, Kilic OH, Gucyetmez V, Savas HA (June 2015). "Phenprobamate dependence: a case report". Addictive Behaviors. 45: 232–3. doi:10.1016/j.addbeh.2015.01.037. PMID 25727392.

[Medscape-3] "(meprobamate) dosing, indications, interactions, adverse effects, and more". Medscape. WebMD LLC. Retrieved 21 March 2024.

Phenprobamate information

and 30 Related for: Phenprobamate information

Phenprobamate

ATC code M03

Meprobamate

Methaqualone

Nitrous oxide

Benzene

Alprazolam

Brazilian Controlled Drugs and Substances Act

Sedative

Ethchlorvynol

Benzodiazepine

Methanol

Insomnia

Kava

Cannabis

Ivermectin

Phenibut

Testosterone

Phenobarbital

Isopropyl alcohol

Dimenhydrinate

Psychiatry

Diazepam

Nitric oxide

Zolpidem

Hypnotic

Temazepam

Flunitrazepam

Propane

Niacin