Nitemazepam information

Nitemazepam
Legal status
Legal status	CA: Schedule IV; DE: NpSG (Industrial and scientific use only); UK: Under Psychoactive Substances Act;
Identifiers
	IUPAC name 7-nitro-3-hydroxy-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one;
CAS Number	40762-03-6;
PubChem CID	12362353;
ChemSpider	64854354;
UNII	DFJ6M9363O;
Chemical and physical data
Formula	C16H13N3O4
Molar mass	311.297 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=[N+](O)c1ccc2c(c1)C(=NC(O)C(=O)N2C)c3ccccc3;
	InChI InChI=1S/C16H13N3O4/c1-18-13-8-7-11(19(22)23)9-12(13)14(17-15(20)16(18)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3; Key:QRWVNMAJJIQCEG-UHFFFAOYSA-N;

Nitemazepam (or 3-hydroxynimetazepam) is a benzodiazepine derivative which was first synthesised in the 1970s but was never marketed. It is the 7-nitro instead of 7-chloro analogue of temazepam, and also the 3-hydroxy derivative of nimetazepam, and an active metabolite. It has in more recent years been sold as a designer drug, first being definitively identified in Europe in 2017. It is metabolized to 7-aminonitemazepam, nimetazepam, 3-hydroxynitemazepam, temazepam, and nimetazepam glucuronide.^[1]^[2]

^ Zawilska JB, Wojcieszak J (July 2019). "An expanding world of new psychoactive substances-designer benzodiazepines". Neurotoxicology. 73: 8–16. doi:10.1016/j.neuro.2019.02.015. PMID 30802466. S2CID 73461430.
^ Moosmann B, Auwärter V (2018). "Designer Benzodiazepines: Another Class of New Psychoactive Substances.". In Maurer H, Brandt S (eds.). New Psychoactive Substances. Handbook of Experimental Pharmacology. Vol. 252. pp. 383–410. doi:10.1007/164_2018_154. ISBN 978-3-030-10560-0. PMID 30367253.

[pmid30802466-1] Zawilska JB, Wojcieszak J (July 2019). "An expanding world of new psychoactive substances-designer benzodiazepines". Neurotoxicology. 73: 8–16. doi:10.1016/j.neuro.2019.02.015. PMID 30802466. S2CID 73461430.

[2] Moosmann B, Auwärter V (2018). "Designer Benzodiazepines: Another Class of New Psychoactive Substances.". In Maurer H, Brandt S (eds.). New Psychoactive Substances. Handbook of Experimental Pharmacology. Vol. 252. pp. 383–410. doi:10.1007/164_2018_154. ISBN 978-3-030-10560-0. PMID 30367253.

Nitemazepam information

and 27 Related for: Nitemazepam information

Nitemazepam

Sedative

Dimenhydrinate

Psychiatry

Insomnia

Kava

Lorazepam

Cannabis

Phenibut

Benzodiazepine

Methaqualone

Zolpidem

Secobarbital

Amitriptyline

Barbiturate

Trazodone

Diphenhydramine

Pentobarbital

Temazepam

Flunitrazepam

Psychoactive drug

Zopiclone

Hypnotic

Sodium thiopental

Lemborexant

Xylazine

Midazolam

Legal status

Legal status	CA: Schedule IV DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act
Identifiers
IUPAC name 7-nitro-3-hydroxy-5-phenyl-1-methyl-1H-benzo[e] [1,4]diazepin-2(3H)-one
CAS Number	40762-03-6
PubChem CID	12362353
ChemSpider	64854354
UNII	DFJ6M9363O
Chemical and physical data
Formula	C₁₆H₁₃N₃O₄
Molar mass	311.297 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=[N+](O)c1ccc2c(c1)C(=NC(O)C(=O)N2C)c3ccccc3
InChI InChI=1S/C16H13N3O4/c1-18-13-8-7-11(19(22)23)9-12(13)14(17-15(20)16(18)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3 Key:QRWVNMAJJIQCEG-UHFFFAOYSA-N