The nigrostriatal pathway is shown here in solid blue, connecting the substantia nigra with the dorsal striatum.
Anatomical terminology
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The nigrostriatal pathway is a bilateral dopaminergic pathway in the brain that connects the substantia nigra pars compacta (SNc) in the midbrain with the dorsal striatum (i.e., the caudate nucleus and putamen) in the forebrain. It is one of the four major dopamine pathways in the brain, and is critical in the production of movement as part of a system called the basal ganglia motor loop. Dopaminergic neurons of this pathway release dopamine from axon terminals that synapse onto GABAergic medium spiny neurons (MSNs), also known as spiny projection neurons (SPNs),[1][2] located in the striatum.
Degeneration of dopaminergic neurons in the SNc is one of the main pathological features of Parkinson's disease,[3] leading to a marked reduction in dopamine function and the symptomatic motor deficits of Parkinson's disease including hypokinesia, tremors, rigidity, and postural imbalance.
^David Smith, A.; Paul Bolam, J. (1990-07-01). "The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones". Trends in Neurosciences. 13 (7): 259–265. doi:10.1016/0166-2236(90)90106-K. ISSN 0166-2236. PMID 1695400. S2CID 4018397.
The nigrostriatalpathway is a bilateral dopaminergic pathway in the brain that connects the substantia nigra pars compacta (SNc) in the midbrain with...
pathway, the mesocortical pathway, the nigrostriatalpathway, and the tuberoinfundibular pathway. The mesolimbic pathway and the mesocortical pathway...
elderly). Although Parkinson's disease is primarily a disease of the nigrostriatalpathway and not the extrapyramidal system, loss of dopaminergic neurons...
the trend was toward naming pathways by their origin and termination.[citation needed] For example, the nigrostriatalpathway runs from the substantia nigra...
Boireau A, Bloch B, Gross CE (August 2000). "Adaptive changes in the nigrostriatalpathway in response to increased 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced...
from brainstem regions, including the ventral tegmental area and nigrostriatalpathway. The MFB passes through the lateral hypothalamus and the basal forebrain...
modulated by various parts of the central nervous system, including the nigrostriatalpathway, the basal ganglia, the cerebellum, the vestibular nuclei, and different...
dopamine in thirst regulation involved the nigrostriatalpathway. After completely degenerating the pathway, the animal becomes adipsic, aphagic, and loses...
striatum. The nigral dopaminergic input to the striatum via the nigrostriatalpathway is intimately linked with the striatum's function. The co-dependence...
been found to be involved in responding to cues related to the reward pathway, enhancing signal detection and sensory attention, regulating homeostasis...
each other and with dopamine directly. In the basal ganglia, the nigrostriatalpathway is where GABA and dopamine are housed in the same neurons and released...
is the substantia nigra which is an important part of the nigrostriatalpathway. This pathway serves to coordinate motor movements and when left unbalanced...
of akinetic mutism suggest a possible presynaptic deficit in the nigrostriatalpathway, which transmits dopamine. Some patients with akinetic mutism have...
histamine—from cellular cytosol into synaptic vesicles. In nigrostriatalpathway and mesolimbic pathway dopamine-releasing neurons, SLC18A2 function is also...
substantia nigra pars compacta to the dorsal striatum, termed the nigrostriatalpathway, plays a significant role in the control of motor function and in...
resulting in the loss of dopaminergic nerve terminals along the nigrostriatalpathway, similar to idiopathic PD, MSA, PSP, CBD, and DLB. Barrett KE, Barman...
primarily from neuroleptic-induced dopamine supersensitivity in the nigrostriatalpathway, with the D2 dopamine receptor being most affected. Neuroleptics...
blockers and benzodiazepines Parkinsonism due to effects on the nigrostriatalpathway - includes tremors, bradykinesia and muscle rigidity risk factors...
on striatal GABAergic medium spiny neurons. Dysregulation of the nigrostriatalpathway is causative from Parkinson disease (PD) in humans. Toxic and/or...
neurotransmission in the dopaminergic pathways that project to the striatum (i.e., the mesolimbic pathway and nigrostriatalpathway). Approximately 5% of the population...
p-quinone can be obtained. Oxidopamine is directly injected into the nigrostriatalpathway, targeting the dopamine transporters (DAT). This can be done through...
neurons of the pars compacta project many of their axons along the nigrostriatalpathway to the dorsal striatum, where they release the neurotransmitter...
resulting in the loss of dopaminergic nerve terminals along the nigrostriatalpathway, similar to idiopathic PD, MSA, PSP, CBD, and DLB. Hodos W (2009)...
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