Skeletal structural formula of Haloperidol, a typical antipsychotic
Class identifiers
Use
Schizophrenia, bipolar disorder, nausea and vomiting, etc.
ATC code
N05A
Biological target
Dopamine receptors
External links
MeSH
D012559
Legal status
In Wikidata
Not to be confused with dopamine reuptake inhibitor or dopamine agonist.
A dopamine antagonist, also known as an anti-dopaminergic and a dopamine receptor antagonist (DRA), is a type of drug which blocks dopamine receptors by receptor antagonism. Most antipsychotics are dopamine antagonists, and as such they have found use in treating schizophrenia, bipolar disorder, and stimulant psychosis.[1] Several other dopamine antagonists are antiemetics used in the treatment of nausea and vomiting.
^Beaulieu JM, Gainetdinov RR (March 2011). "The physiology, signaling, and pharmacology of dopamine receptors". Pharmacological Reviews. 63 (1): 182–217. doi:10.1124/pr.110.002642. PMID 21303898. S2CID 2545878.
and 29 Related for: Dopamine antagonist information
A dopamineantagonist, also known as an anti-dopaminergic and a dopamine receptor antagonist (DRA), is a type of drug which blocks dopamine receptors...
levels of dopamine activity, and most antipsychotic drugs used to treat this are dopamineantagonists which reduce dopamine activity. Similar dopamine antagonist...
antipsychotic drugs such as chlorpromazine and haloperidol are antagonists for the dopamine D2 receptor, but are, in general, very unselective, at best selective...
also known as second generation antipsychotics (SGAs) and serotonin–dopamineantagonists (SDAs), are a group of antipsychotic drugs (antipsychotic drugs in...
A dopamine agonist (DA) is a compound that activates dopamine receptors. There are two families of dopamine receptors, D1-like and D2-like. They are all...
targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. The existence of...
as an antagonist by blocking dopamine receptors. When endogenous dopamine levels are low, cariprazine acts more as an agonist, increasing dopamine receptor...
A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action...
Antagonists of the 5-HT2A receptor are sometimes used as atypical antipsychotics (contrast with typical antipsychotics, which are purely dopamine antagonists)...
large number of antipsychotics have dopamine-receptor antagonistic effects. The theory, however, does not posit dopamine overabundance as a complete explanation...
receptor antagonists. The introduction of aripiprazole has led to a paradigm shift from a dopamineantagonist-based approach to a dopamine agonist-based...
The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5. The structure of DRD4 has...
Domperidone, sold under the brand name Motilium among others, is a dopamineantagonist medication which is used to treat nausea and vomiting and certain...
medication. Cocaine blocks a dopamine transporter responsible for the reuptake of dopamine. Without the transporter, dopamine diffuses much more slowly from...
belong to this group, as it is a serotonin–dopamine reuptake inhibitor and 5-HT2A and 5-HT2C receptor antagonist, but not grouped as such. Lubazodone (YM-992...
Ecopipam (development codes SCH-39166, EBS-101, and PSYRX-101) is a dopamineantagonist which is under development for the treatment of Lesch-Nyhan syndrome...
the empirical response of some antipsychotics and their antagonistic effects on the dopamine receptor. However, it is important to outline that the hypothesis...
not entirely clear but believed to be related to its ability as a dopamineantagonist. It also has anti-serotonergic and antihistaminergic properties....
1963, the administration of chlorpromazine marked the advent of the dopamineantagonist, or first generation antipsychotic. While clinical trials showed...
antipsychotics such as sulpiride and amisulpride known for their dopamineantagonist effects. Research in animal models and clinical studies in alcoholic...
derivative being the prototypical antagonist SCH-23390). D1 receptor has a high degree of structural homology to another dopamine receptor, D5, and they both...
H3R antagonists in ADHD to aid in attention and cognitive activity by elevating release of neurotransmitters such as acetylcholine and dopamine. In schizophrenia...
known as α-blockers or α-adrenoreceptor antagonists, are a class of pharmacological agents that act as antagonists on α-adrenergic receptors (α-adrenoceptors)...
selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor. It is an analog of spiperone and also has some dopamineantagonist effects...
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than...
receptor antagonists or inverse agonists. Normally, histamine binds to the H1 receptor and heightens the receptor's activity; the receptor antagonists work...
dextrose agar , microbiological media allows fungus to grow Serotonin–dopamineantagonist, atypical antipsychotic Specific dynamic action, the thermic effect...
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