Global InformationAdipsia information
| Adipsia | |
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| Other names | hypodipsia |
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| Molecular structure of vasopressin. This hormone is related to Type A and Type B adipsia. | |
Adipsia, also known as hypodipsia, is a symptom of inappropriately decreased or absent feelings of thirst.[1][2] It involves an increased osmolality or concentration of solute in the urine, which stimulates secretion of antidiuretic hormone (ADH) from the hypothalamus to the kidneys. This causes the person to retain water and ultimately become unable to feel thirst. Due to its rarity, the disorder has not been the subject of many research studies.
Adipsia may be seen in conditions such as diabetes insipidus[3] and may result in hypernatremia.[4] It can occur as the result of abnormalities in the hypothalamus, pituitary and corpus callosum,[5] as well as following pituitary/hypothalamic surgery.[6]
It is possible for hypothalamic dysfunction, which may result in adipsia, to be present without physical lesions in the hypothalamus, although there are only four reported cases of this.[7] There are also some cases of patients experiencing adipsia due to a psychiatric disease. In these rare psychogenic cases, the patients have normal levels of urine osmolality as well as typical ADH activity.[8]
- ^ "adipsia | pathology". Encyclopædia Britannica. Retrieved 2016-04-26.
- ^ Lin, M; Liu, SJ; Lim, IT (August 2005). "Disorders of water imbalance". Emergency Medicine Clinics of North America. 23 (3): 749–70, ix. doi:10.1016/j.emc.2005.03.001. PMID 15982544.
- ^ Crowley, R. K.; Sherlock, M.; Agha, A.; Smith, D.; Thompson, C. J. (2007). "Clinical insights into adipsic diabetes insipidus: a large case series". Clinical Endocrinology. 66 (4): 475–82. doi:10.1111/j.1365-2265.2007.02754.x. PMID 17371462. S2CID 28845882.
- ^ Cite error: The named reference
:1was invoked but never defined (see the help page). - ^ Kim, Boo Gyoung; Kim, Ka Young; Park, Youn Jeong; Yang, Keun Suk; Kim, Ji Hee; Jung, Hee Chan; Nam, Hee Chul; Kim, Young Ok; Yun, Yu Seon (2012). "A Case of Adipsic Hypernatremia Associated with Anomalous Corpus Callosum in Adult with Mental Retardation". Endocrinology and Metabolism. 27 (3): 232–6. doi:10.3803/EnM.2012.27.3.232.
- ^ Sherlock, M.; Agha, A.; Crowley, R.; Smith, D.; Thompson, C. J. (2006). "Adipsic diabetes insipidus following pituitary surgery for a macroprolactinoma". Pituitary. 9 (1): 59–64. doi:10.1007/s11102-006-8280-x. PMID 16703410. S2CID 8678093.
- ^ Hayek, A; Peake, GT (1982). "Hypothalamic adipsia without demonstrable structural lesion". Pediatrics. 70 (2): 275–8. doi:10.1542/peds.70.2.275. PMID 6808452. S2CID 32259354.
- ^ Harrington, C.; Grossman, J.; Richman, K. (2014). "Psychogenic adipsia presenting as acute kidney injury: case report and review of disorders of sodium and water metabolism in psychiatric illness". Psychosomatics. 55 (3): 289–295. doi:10.1016/j.psym.2013.06.013. PMID 24012289.