Group of dopamine neurons that project from arcuate nucleus in hypothalamus
Tuberoinfundibular pathway shown in opaque blue, connecting that hypothalamus with the pituitary gland.
The tuberoinfundibular pathway refers to a population of dopamine neurons that project from the arcuate nucleus (a.k.a. the "infundibular nucleus") in the tuberal region of the hypothalamus to the median eminence.[1] It is one of the four major dopamine pathways in the brain. Dopamine released at this site inhibits the secretion of prolactin from anterior pituitary gland lactotrophs by binding to D2 receptors.
Some antipsychotic drugs block dopamine in the tuberoinfundibular pathway, which can cause an increase in the amount of prolactin in the blood (hyperprolactinemia).
^Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 10: Neural and Neuroendocrine Control of the Internal Milieu". In Sydor A, Brown RY (eds.). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. p. 249. ISBN 9780071481274. Relationship of the hypothalamus and the pituitary gland. The anterior pituitary, or adenohypophysis, receives rich blood flow from the capillaries of the portal hypophyseal system. This system delivers factors released by hypothalamic neurons into portal capillaries at the median eminence. The figure shows one such projection, from the tuberal (arcuate) nuclei via the tuberoinfundibular tract to the median eminence.
and 21 Related for: Tuberoinfundibular pathway information
The tuberoinfundibularpathway refers to a population of dopamine neurons that project from the arcuate nucleus (a.k.a. the "infundibular nucleus") in...
pathway, the mesocortical pathway, the nigrostriatal pathway, and the tuberoinfundibularpathway. The mesolimbic pathway and the mesocortical pathway...
been found to be involved in responding to cues related to the reward pathway, enhancing signal detection and sensory attention, regulating homeostasis...
hypothalamus have dopamine neurons that form an important projection—the tuberoinfundibularpathway which goes to the pituitary gland, where it influences the secretion...
propiomazine. Propiomazine does not appear to block dopamine within the tuberoinfundibularpathway, which may explain its lower incidence of hyperprolactinemia than...
effects in several pathways of the dopamine system. In the nigrostratial pathway, it reduces EPS. In the tuberoinfundibularpathway, it reduces or eliminates...
destroyed in the liver. Each neurotransmitter has very specific degradation pathways at regulatory points, which may be targeted by the body's regulatory system...
result from hypopituitarism, excessive dopaminergic action in the tuberoinfundibularpathway and ingestion of D2 receptor agonists such as bromocriptine.[citation...
deficiency, hypothyroidism, excessive dopamine action in the tuberoinfundibularpathway and/or the anterior pituitary, and ingestion of drugs that activate...
risperidone blocks the mesolimbic pathway, the prefrontal cortex limbic pathway, and the tuberoinfundibularpathway in the central nervous system. Risperidone...
of dopamine antagonists as blockade of D2 receptors within the tuberoinfundibularpathway results in increased plasma levels of prolactin due to increased...
the mesocortical pathway, tuberoinfundibularpathway, and the nigrostriatal pathway. Blocking D2 receptors in these other pathways is thought to produce...
elicit normal effects in areas such as the nigrostriatal and tuberoinfundibularpathways, thus minimizing the risk of side-effects such as pseudo-parkinsonism...
Tuberoinfundibular peptide of 39 residues is a protein that in humans is encoded by the PTH2 gene. TIP39 is related to parathyroid hormone (PTH; MIM 168450)...
nucleus. Groups of neuroendocrine neurons include: TIDA neurons, or tuberoinfundibular dopamine neurons, are neurons that regulate the secretion of prolactin...
Hoare SR, Clark JA, Usdin TB (2000). "Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2...
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