Keratan sulfate (KS), also called keratosulfate, is any of several sulfated glycosaminoglycans (structural carbohydrates) that have been found especially in the cornea, cartilage, and bone. It is also synthesized in the central nervous system where it participates both in development[1] and in the glial scar formation following an injury.[2] Keratan sulfates are large, highly hydrated molecules which in joints can act as a cushion to absorb mechanical shock.
^Miller B, Sheppard AM, Pearlman AL (April 1997). "Developmental expression of keratan sulfate-like immunoreactivity distinguishes thalamic nuclei and cortical domains". J. Comp. Neurol.380 (4): 533–52. doi:10.1002/(SICI)1096-9861(19970421)380:4<533::AID-CNE9>3.0.CO;2-2. PMID 9087531.
^Zhang H, Uchimura K, Kadomatsu K (November 2006). "Brain keratan sulfate and glial scar formation". Ann. N. Y. Acad. Sci.1086 (1): 81–90. Bibcode:2006NYASA1086...81Z. doi:10.1196/annals.1377.014. PMID 17185507.
Keratansulfate (KS), also called keratosulfate, is any of several sulfated glycosaminoglycans (structural carbohydrates) that have been found especially...
uronic sugar and an amino sugar, except in the case of the sulfated glycosaminoglycan keratan, where, in place of the uronic sugar there is a galactose...
had not been studied until recently. Like the chondroitin sulfate proteoglycans, keratansulfate proteoglycan (KSPG) production is up regulated in reactive...
They have also been known to affect neuroplasticity. Keratansulfates have a variable sulfate content and, unlike many other GAGs, do not contain uronic...
Morquio syndrome, the specific GAG which builds up in the body is called keratansulfate. This birth defect, which is autosomal recessive, is a type of lysosomal...
glycosaminoglycan is joined through a tetrasaccharide bridge (e.g. chondroitin sulfate-GlcA-Gal-Gal-Xyl-PROTEIN). The Ser residue is generally in the sequence...
(GALNS) (Type A) or beta-galactosidase (Type B) needed to break down the keratansulfate sugar chain. Clinical features are similar in both types but appear...
disorder preventing the start or completion of puberty Keratansulfate, any of several sulfated glycosaminoglycans Kernel streaming, a method of processing...
proteoglycan. It exhibits a bottlebrush structure, in which chondroitin sulfate and keratansulfate glycosaminoglycan (GAG) chains are attached to an extended protein...
aggrecan molecule are glycosaminoglycan (GAG) chains of chondroitin sulfate and keratansulfate. Increasing the amount of negatively charged aggrecan increases...
adenosine 3',5'-bisphosphate + keratan 6'-sulfate Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and keratan, whereas its two products...
Several classes of sulfate esters exist in nature. Especially common are sugar derivatives such as keratansulfate, chondroitin sulfate, and the anticoagulant...
Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan (HSPG, i.e. Heparan Sulfate ProteoGlycan) in which...
has a fibrocartilaginous structure. The presence of chondroitin and keratansulfate in the dorsal and palmar plates is important in resisting compression...
synthesizing collagen molecules of different types (I, V, VI) and keratansulfate. By the moment of eye opening after birth the proliferation of keratocytes...
leucine-rich repeat domain of the protein core that can be substituted with keratansulfate. The core protein of lumican (like decorin and fibromodulin) is horseshoe...
conjunction with transforming growth factor beta. This protein is a small keratansulfate proteoglycan which contains tandem leucine-rich repeats (LRR). The...
Habuchi O (Jan 1998). "Molecular cloning and characterization of human keratansulfate Gal-6-sulfotransferase". J Biol Chem. 272 (51): 32321–8. doi:10.1074/jbc...
proteins with side chains made of glycosaminoglycans such as keratansulfate and chondroitin sulfate attached to strands of hyaluronic acid. The glycosaminoglycan...
rest of the bone is composed of materials including chondroitin sulfate, keratansulfate and lipid. Increased research and knowledge regarding the organization...
loading. They attach themselves to up to 100 Chondroitin sulfate molecules and up to 50 keratansulfate glycoaminoglycan chains. These chains together are attached...
leucine-rich repeat proteoglycans (SLRPs). It can have up to four N-linked keratansulfate chains attached to the core protein within the leucine-rich region...
and sulfate; glucosamine-6-sulfatase EC 3.1.6.14 (G6S), which hydrolyzes the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate;...
conductivity capabilities of any biological material. It contains keratansulfate in 97% water, and has a conductivity of about 1.8 mS/cm. All animals...
chain. Acharan sulfate is a heparinoid that is naturally produced by the giant African land snail, Lissachatina fulica. Keratansulfate is a heparinoid...
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