Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene.[5] This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage.
Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing.[5] Aggrecan was named for its ability to form large aggregates in the cartilage tissue (a large aggregating proteoglycan).[6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000157766 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030607 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abDoege KJ, Sasaki M, Kimura T, Yamada Y (January 1991). "Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms". J. Biol. Chem. 266 (2): 894–902. doi:10.1016/S0021-9258(17)35257-2. PMID 1985970.
^Aspberg A (December 2012). "The different roles of aggrecan interaction domains". The Journal of Histochemistry and Cytochemistry. 60 (12): 987–96. doi:10.1369/0022155412464376. PMC 3527881. PMID 23019016.
^Chremos A, Horkay F (September 2023). "Coexistence of Crumpling and Flat Sheet Conformations in Two-Dimensional Polymer Networks: An Understanding of Aggrecan Self-Assembly". Physical Review Letters. 131 (13): 138101. Bibcode:2023PhRvL.131m8101C. doi:10.1103/PhysRevLett.131.138101. PMID 37832020. S2CID 263252529.
Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans...
cells, collagen fibrils, and aggrecan, a proteoglycan that aggregates by binding to hyaluronan. Attached to each aggrecan molecule are glycosaminoglycan...
differentiates into chondroblasts and begins secreting the molecules (aggrecan and collagen type II) that form the extracellular matrix. In all vertebrates...
brevican, neurocan, versican, aggrecan, phosphacan, hyaluronan, tenascin-R and various link proteins. The CSPGs aggrecan, versican, neurocan, brevican...
Advisory Committee on Antarctic Names ACAN (gene), a gene coding for the aggrecan protein ACAN-EFE, a news agency Akan (disambiguation) Achan (disambiguation)...
tissue) components including decorin and, in compressed regions of tendon, aggrecan, which are capable of binding to the collagen fibrils at specific locations...
aggrecan, a major proteoglycan of cartilage, brevican, a brain-specific extracellular matrix protein, neurocan and versican. The cleavage of aggrecan...
For example, in the cornea and cartilage, the keratan sulfate domain of aggrecan consists of a series of tandemly repeated hexapeptides with a consensus...
include type I collagen (sp1 site), type IX collagen, vitamin D receptor, aggrecan, asporin, MMP3, interleukin-1, and interleukin-6 polymorphisms. Mutation...
family: aggrecan, brevican, neurocan, and versican. Lecticans interact with hyaluronic acid and tenascin-R to form a ternary complex. Aggrecan is a major...
N-acetylglucosamine or N-acetylgalactosamine. The following CSPGs have been identified: Aggrecan (CSPG1) Versican (CSPG2) Neurocan (CSPG3) CSPG4 (melanoma-associated chondroitin...
glycoproteins, collagen types II, IX, X, and XI, and the proteoglycan aggrecan. the components within the extracellular matrix are produced by the chondroblasts...
contain the link domain include: the hyalectans (a family of proteoglycans): aggrecan, brevican, neurocan and versican, which are expressed in the CNS; the cartilage...
cartilage, where it is present as a coat around each cell (chondrocyte). When aggrecan monomers bind to hyaluronan in the presence of HAPLN1 (hyaluronic acid...
processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of...
include type I collagen (sp1 site), type IX collagen, vitamin D receptor, aggrecan, asporin, MMP3, interleukin-1, and interleukin-6 polymorphisms. Mutation...
"Mechanotransduction via integrins and interleukin–4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic...
modular structure. Versican belongs to the lectican protein family, with aggrecan (abundant in cartilage), brevican and neurocan (nervous system proteoglycans)...
MMP-8, PMNL-CL secreted Substrates include Col I, II, III, VII, VIII, X, aggrecan, gelatin MMP9 Gelatinase-B, 92 kDa gelatinase CLG4B, GELB, MANDP2, MMP-9...
the extracellular matrix (ECM) including fibronectin, vitronectin and aggrecan. Cleavage can cause cell death by anoikis and release alarmins from the...
Kelly G, Brumberg JC, Matthews RT (May 2007). "Sensory deprivation alters aggrecan and perineuronal net expression in the mouse barrel cortex". The Journal...
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