Global InformationPolysulfated glycosaminoglycan information
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 Chemical structure and packaging | |
| Clinical data | |
|---|---|
| Trade names | Adequan |
| AHFS/Drugs.com | Veterinary Use |
| License data |
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| Routes of administration | Usually IM or IA |
| ATCvet code |
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| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Protein binding | 30–40% |
| Metabolism | Renal |
| Onset of action | 48 hours for peak levels in joints (IM) |
| Duration of action | 96 hours (IM) |
| Excretion | Urine |
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| Chemical and physical data | |
| Molar mass | 3,000–15,000 Da |
Polysulfated glycosaminoglycan (PSGAG), sold under the brand name Adequan, is an injectable drug for dogs and horses that is used to alleviate the limpness, pain, and lowered range of motion caused by arthritis.[2] It is made of repeat disaccharide units (comprising hexosamine and hexuronic acid), and is similar to glycosaminoglycans already present in the cartilage; PSGAG thus easily integrates itself there.[3][4] In vitro studies have shown it to inhibit the enzymes that degrade cartilage and bone, as well as suppress inflammation and stimulate the synthesis of replacement cartilage. While it can cause an increased risk of bleeding, it is relatively safe and has a high LD50. PSGAG is one of the most widely prescribed joint treatments for horses.[5]
While it is widely used, some studies still show conflicting results in terms of efficacy, causing some to claim that PSGAG is not solely responsible for the significant mitigation of arthritis seen in success cases.[6]
- ^ Cite error: The named reference
plumbwas invoked but never defined (see the help page). - ^ Goldberg ME (2014-10-23). Pain Management for Veterinary Technicians and Nurses. John Wiley & Sons. p. 140. ISBN 9781118811160.
- ^ Wanamaker BP, Massey K (2014-03-25). Applied Pharmacology for Veterinary Technicians - E-Book. Elsevier Health Sciences. p. 392. ISBN 9780323291705.
- ^ White GW (1988-11-01). "Adequan: A review for the practicing veterinarian". Journal of Equine Veterinary Science. 8 (6): 463–468. doi:10.1016/S0737-0806(88)80096-0. ISSN 0737-0806.
- ^ Bryant JO (2012-12-10). The USDF Guide to Dressage: The Official Guide of the United States Dressage Foundation. Storey Publishing. p. 285. ISBN 9781612122748.
- ^ Schulz K, Beale B, Holsworth I (2005). The Pet Lover's Guide to Canine Arthritis & Joint Problems. Elsevier Health Sciences. p. 192. ISBN 9781416026143.
