Birth; condition usually becomes apparent between ages 1 and 3
Duration
Lifelong
Types
Type A and Type B
Causes
Inherited deficiency of enzymes
Treatment
Elosulfase alfa (Vimizim) for Type A; no approved treatment for Type B
Prognosis
Reduced lifespan. Usually death occurs in 20s to 30s
Frequency
1 in 200,000 to 1 in 300,000
Morquio syndrome, also known as mucopolysaccharidosis type IV (MPS IV), is a rare metabolic disorder in which the body cannot process certain types of sugar molecules called glycosaminoglycans (AKA GAGs, or mucopolysaccharides). In Morquio syndrome, the specific GAG which builds up in the body is called keratan sulfate. This birth defect, which is autosomal recessive, is a type of lysosomal storage disorder. The buildup of GAGs in different parts of the body causes symptoms in many different organ systems.[2]: 544 In the US, the incidence rate for Morquio syndrome is estimated at between 1 in 200,000 and 1 in 300,000 live births.[1][3]
^ ab"MPS IV (Morquio syndrome)". MPSSociety.org. National MPS Society. Archived from the original on 21 August 2017. Retrieved 14 January 2015.
^James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
^Prat C, Lemaire O, Bret J, Zabraniecki L, Fournié B (May 2008). "Morquio syndrome: Diagnosis in an adult". Joint Bone Spine. 75 (4): 495–8. doi:10.1016/j.jbspin.2007.07.021. PMID 18456538.
Morquiosyndrome, also known as mucopolysaccharidosis type IV (MPS IV), is a rare metabolic disorder in which the body cannot process certain types of...
The incidence of Sanfilippo syndrome (for all four types combined) is about one in 70,000 births. MPS IV, Morquiosyndrome, is estimated to occur in 1...
Birch. His short physical stature (3 ft 1 in (0.94 m)) is a result of Morquiosyndrome, a rare enzymatic disorder affecting the circulatory, muscular and...
physically disabled but very intelligent. Kevin is diagnosed with Morquiosyndrome. The novel was adapted for the screen under the title The Mighty by...
retardation (X-linked Raynaud type) Miescher's syndromeMorquiosyndromeMorquiosyndrome type A Morquiosyndrome type B MPS 3 C MPS 3 D Mucolipidosis III...
spondyloepiphyseal dysplasia, mucopolysaccharide metabolism disorders (Morquiosyndrome and Hurler's syndrome), deafness and also in hypothyroidism. Some links have been...
acting since. Smith was chosen because of his small height, due to Morquiosyndrome. A hospital worker in Chicago suggested Smith try out for a role in...
the brand name Vimizim, is a medication used for the treatment of Morquiosyndrome which is caused by a deficiency in the enzyme N-acetylgalactosamine-6-sulfatase...
Luis Morquio (September 24, 1867 – June 19, 1935) was a Uruguayan physician and professor. A medical condition, Morquiosyndrome (mucopolysaccharidosis...
performance. Kevin "Freak" Dillon is a 12-year-old boy suffering from Morquiosyndrome and living with his mother Gwen "Fair Gwen" Dillon. He is extremely...
film Antz, and played the mother of a 13-year-old boy suffering from Morquiosyndrome in the drama The Mighty, which garnered a positive critical response...
Lange syndrome – Winfried Robert Clemens Brachmann, Cornelia Catharina de Lange Brailsford–Morquiosyndrome – James Frederick Brailsford, Luís Morquio Brandt...
(see Morquiosyndrome) MPS VI Mucopolysaccharoidosis type VI (see Maroteaux–Lamy syndrome) MPS VII Mucopolysaccharoidosis type VII (see Sly syndrome) MPX...
Joyce Carpenter (December 21, 1929 – August 7, 1973), suffered from Morquiosyndrome. At 74 cm or 29ins the shortest recorded adult in the UK. Wybrand Lolkes...
where this feature is absent. N-Acetylglucosamine Galactose Lumican Morquiosyndrome is marked by the accumulation of KS Proteoglycan 4 Miller B, Sheppard...
Vimizim), is the only enzyme replacement therapy to address the cause of Morquio A Syndrome (MPS IVA), which affects an estimated 3,000 patients in the developed...
be caused by a deficiency of β-galactosidase (GLB1). Some cases of Morquiosyndrome B have been shown to be due to GLP1 mutations that cause patients to...