Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.[5]
This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small keratan sulfate proteoglycan[6] which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.[5]
The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.[7][8]
^ abcGRCh38: Ensembl release 89: ENSG00000106809 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021390 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ab"Entrez Gene: OGN osteoglycin".
^Funderburgh JL, Corpuz LM, Roth MR, Funderburgh ML, Tasheva ES, Conrad GW (1997). "Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a product of the gene producing osteoglycin". J Biol Chem. 272 (44): 28089–95. doi:10.1074/jbc.272.44.28089. PMID 9346963.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein. This gene encodes a protein which induces ectopic bone formation in conjunction...
compensatory mechanism.[citation needed] Associated genes include OGN, osteoglycin. The commonly used method to diagnose LVH is echocardiography, with which...
includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. Like the other SLRPs, lumican has a molecular weight of about 40 kilodaltons...