Interleukin 5 receptor alpha subunit information

IL5RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OBX, 1OBZ, 3QT2, 3VA2
Identifiers
Aliases	IL5RA, CD125, CDw125, HSIL5R3, IL5R, Interleukin 5 receptor alpha subunit, interleukin 5 receptor subunit alpha
External IDs	OMIM: 147851; MGI: 96558; HomoloGene: 473; GeneCards: IL5RA; OMA:IL5RA - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	3,126,613 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	106,725,998 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; olfactory zone of nasal mucosa; ; bronchial epithelial cell; ; gonad; ; bone marrow; ; blood; ; bone marrow cells; ; rectum; ; gallbladder; ; monocyte;
	Top expressed in
	right kidney; ; blood; ; proximal tubule; ; mesenteric lymph nodes; ; morula; ; spleen; ; human kidney; ; thymus; ; uterus; ; CA3 field;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	interleukin-5 receptor activity; protein binding; cytokine receptor activity; protein tyrosine kinase activity; cytokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; intracellular anatomical structure; extracellular space; external side of plasma membrane; receptor complex;
Biological process	cellular response to organic substance; inflammatory response to antigenic stimulus; regulation of interleukin-5 production; MAPK cascade; cell population proliferation; signal transduction; interleukin-5-mediated signaling pathway; peptidyl-tyrosine phosphorylation; cytokine-mediated signaling pathway; positive regulation of leukocyte proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3568
	16192
	ENSG00000091181
	ENSMUSG00000005364
	Q01344
	P21183
NM_000564; NM_001243099; NM_175724; NM_175725; NM_175726;
	NM_175727; NM_175728
	NM_008370
NP_000555; NP_001230028; NP_783851; NP_783852; NP_783853;
	NP_783854; NP_783855
	NP_032396
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091181 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005364 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IL5RA interleukin 5 receptor, alpha".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091181 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005364 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IL5RA interleukin 5 receptor, alpha".

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