IKBKG information

IKBKG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JVX, 2JVY, 3BRT, 3BRV, 3CL3, 3FX0, 4BWN, 5AAY
Identifiers
Aliases	IKBKG, AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKKAP1, IKKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, inhibitor of nuclear factor kappa B kinase subunit gamma, EDAID1, inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
External IDs	OMIM: 300248 MGI: 1338074 HomoloGene: 2698 GeneCards: IKBKG
Gene location (Human)
Chr.	X chromosome (human)
End	154,565,046 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,497,460 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; right lobe of liver; ; upper lobe of left lung; ; left adrenal gland; ; monocyte; ; right lung; ; gastric mucosa; ; right lobe of thyroid gland; ; body of stomach;
	Top expressed in
	left lobe of liver; ; blood; ; ankle; ; epithelium of stomach; ; condyle; ; endocardial cushion; ; adrenal gland; ; temporal muscle; ; Paneth cell; ; sciatic nerve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein domain specific binding; signal transducer activity; metal ion binding; protein binding; linear polyubiquitin binding; ubiquitin protein ligase binding; identical protein binding; K63-linked polyubiquitin modification-dependent protein binding; peroxisome proliferator activated receptor binding; protein heterodimerization activity;
Cellular component	cytoplasm; spindle pole; ubiquitin ligase complex; intracellular anatomical structure; IkappaB kinase complex; mitotic spindle; nucleus; cytosol; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; regulation of tumor necrosis factor-mediated signaling pathway; response to virus; stimulatory C-type lectin receptor signaling pathway; transcription, DNA-templated; TRIF-dependent toll-like receptor signaling pathway; Fc-epsilon receptor signaling pathway; JNK cascade; positive regulation of NF-kappaB transcription factor activity; stress-activated MAPK cascade; immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; innate immune response; inflammatory response; viral process; I-kappaB kinase/NF-kappaB signaling; T cell receptor signaling pathway; nucleotide-binding oligomerization domain containing signaling pathway; establishment of vesicle localization; positive regulation of transcription by RNA polymerase II; negative regulation of neuron death; apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cellular response to DNA damage stimulus; positive regulation of macroautophagy; protein deubiquitination; anoikis; MyD88-independent toll-like receptor signaling pathway; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8517
	16151
	ENSG00000269335
	ENSMUSG00000004221
	Q9Y6K9
	O88522
NM_001099856; NM_001099857; NM_001145255; NM_003639; NM_001321396;
	NM_001321397; NM_001377312; NM_001377313; NM_001377314; NM_001377315
NM_001136067; NM_001161421; NM_001161422; NM_001161423; NM_001161424;
	NM_010547; NM_178590
NP_001093326; NP_001093327; NP_001138727; NP_001308325; NP_001308326;
	NP_003630; NP_001364241; NP_001364242; NP_001364243; NP_001364244
NP_001129539; NP_001154893; NP_001154894; NP_001154895; NP_001154896;
	NP_034677; NP_848705
	Wikidata
View/Edit Human	View/Edit Mouse

NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB.^[5] The human gene for IKBKG is located on the chromosome band Xq28.^[6] Multiple transcript variants encoding different isoforms have been found for this gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000269335 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004221 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rothwarf DM, Zandi E, Natoli G, Karin M (September 1998). "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex". Nature. 395 (6699): 297–300. Bibcode:1998Natur.395..297R. doi:10.1038/26261. PMID 9751060. S2CID 4421659.
^ Jin DY, Jeang KT (1999). "Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28". Journal of Biomedical Science. 6 (2): 115–20. doi:10.1159/000025378. PMID 10087442. S2CID 202651606.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000269335 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004221 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9751060-5] Rothwarf DM, Zandi E, Natoli G, Karin M (September 1998). "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex". Nature. 395 (6699): 297–300. Bibcode:1998Natur.395..297R. doi:10.1038/26261. PMID 9751060. S2CID 4421659.

[pmid10087442-6] Jin DY, Jeang KT (1999). "Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28". Journal of Biomedical Science. 6 (2): 115–20. doi:10.1159/000025378. PMID 10087442. S2CID 202651606.

IKBKG information

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