IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. IRAK4 contains domain structures which are similar to those of IRAK1, IRAK2, IRAKM and Pelle. IRAK4 is unique compared to IRAK1, IRAK2 and IRAKM in that it functions upstream of the other IRAKs, but is more similar to Pelle in this trait. IRAK4 has important clinical applications.
Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.
^ abcGRCh38: Ensembl release 89: ENSG00000198001 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000059883 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
signaling from T-cell receptors. IRAK4 contains domain structures which are similar to those of IRAK1, IRAK2, IRAKM and Pelle. IRAK4 is unique compared to IRAK1...
the TLRs on macrophages and dendritic cells. MyD88 attracts the IRAK4 molecule, IRAK4 recruits IRAK1 and IRAK2 to form a signaling complex. The signaling...
(March 2014). "Functional assessment of the mutational effects of human IRAK4 and MyD88 genes". Molecular Immunology. 58 (1): 66–76. doi:10.1016/j.molimm...
Signaling through Its Interaction with the IL-1 Receptor-associated Kinase 4 (IRAK4)-IRAK-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Complex"...
TRAM. These adapters activate other intracellular molecules such as IRAK1, IRAK4, TBK1, and IKKi that amplify the signal, eventually leading to the induction...
structures provide complete coordinates for the substrate activation loop) human IRAK4, Thr345 (PDB: 4U97, 4U9A) N or C terminal tails Ser/Thr phosphorylation...
signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex"...
Wesche H (Jul 2003). "Characterization of Pellino2, a substrate of IRAK1 and IRAK4". FEBS Lett. 547 (1–3): 157–61. doi:10.1016/S0014-5793(03)00697-5. PMID 12860405...
soluble forms are known. The protein is known to interact with MyD88, IRAK1, IRAK4 and TRAF6. It appears to be essential for the normal function of T helper...