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IRAK4 information


IRAK4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIRAK4, IPD1, IRAK-4, NY-REN-64, REN64, interleukin 1 receptor associated kinase 4, IMD67
External IDsOMIM: 606883 MGI: 2182474 HomoloGene: 41109 GeneCards: IRAK4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_029926

RefSeq (protein)

NP_084202

Location (UCSC)Chr 12: 43.76 – 43.8 MbChr 15: 94.44 – 94.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. IRAK4 contains domain structures which are similar to those of IRAK1, IRAK2, IRAKM and Pelle. IRAK4 is unique compared to IRAK1, IRAK2 and IRAKM in that it functions upstream of the other IRAKs, but is more similar to Pelle in this trait. IRAK4 has important clinical applications.

Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198001 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059883 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

and 14 Related for: IRAK4 information

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IRAK4

Last Update:

signaling from T-cell receptors. IRAK4 contains domain structures which are similar to those of IRAK1, IRAK2, IRAKM and Pelle. IRAK4 is unique compared to IRAK1...

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Pattern recognition receptor

Last Update:

the TLRs on macrophages and dendritic cells. MyD88 attracts the IRAK4 molecule, IRAK4 recruits IRAK1 and IRAK2 to form a signaling complex. The signaling...

Word Count : 5164

Innate immune defect

Last Update:

(March 2014). "Functional assessment of the mutational effects of human IRAK4 and MyD88 genes". Molecular Immunology. 58 (1): 66–76. doi:10.1016/j.molimm...

Word Count : 1137

Scaffold protein

Last Update:

Signaling through Its Interaction with the IL-1 Receptor-associated Kinase 4 (IRAK4)-IRAK-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Complex"...

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Signal transduction

Last Update:

TRAM. These adapters activate other intracellular molecules such as IRAK1, IRAK4, TBK1, and IKKi that amplify the signal, eventually leading to the induction...

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Autophosphorylation

Last Update:

structures provide complete coordinates for the substrate activation loop) human IRAK4, Thr345 (PDB: 4U97, 4U9A) N or C terminal tails Ser/Thr phosphorylation...

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Tyrosine kinase

Last Update:

FGFR4; FGR; FLT1; FLT3; FLT4; FRK; FYN; GSG2; HCK; IGF1R; ILK; INSR; INSRR; IRAK4; ITK; JAK1; JAK2; JAK3; KDR; KIT; KSR1; LCK; LMTK2; LMTK3; LTK; LYN; MATK;...

Word Count : 5251

Protein kinase domain

Last Update:

ICK ; IGF1R ; IKBKB ; IKBKE ; ILK ; INSR ; INSRR ; IRAK1 ; IRAK2 ; IRAK3 ; IRAK4 ; ITK ; JAK1 ; JAK2 ; JAK3 ; KALRN ; KDR ; KIT ; KSR1 ; KSR2 ; LATS1 ; LATS2 ;...

Word Count : 1569

List of primary immunodeficiencies

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CD16 deficiency IRF8 deficiency IFNAR2 deficiency TLR pathway deficiencies IRAK4 deficiency IRAK1 deficiency MyD88 deficiency TIRAP deficiency MDA5 deficiency...

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PELI1

Last Update:

signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex"...

Word Count : 510

Outline of immunology

Last Update:

TLR9 TLR10 TLR11 TLR12 TLR13 Other receptors CD14 LBP MD2 Downstream signalling IRAK1 IRAK2 IRAK3 IRAK4 IRF3 MAP3K7 MYD88 TAB1 TICAM1 TIRAP TOLLIP TRAF6...

Word Count : 2656

PELI2

Last Update:

Wesche H (Jul 2003). "Characterization of Pellino2, a substrate of IRAK1 and IRAK4". FEBS Lett. 547 (1–3): 157–61. doi:10.1016/S0014-5793(03)00697-5. PMID 12860405...

Word Count : 391

IL1RL1

Last Update:

soluble forms are known. The protein is known to interact with MyD88, IRAK1, IRAK4 and TRAF6. It appears to be essential for the normal function of T helper...

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List of OMIM disorder codes

Last Update:

Invasive pneumococcal disease, recurrent isolated, 1; 610799; IRAK4 IRAK4 deficiency; 607676; IRAK4 Iridogoniodysgenesis, type 1; 601631; FOXC1 Iridogoniodysgenesis...

Word Count : 18877

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