Epigenetics of neurodegenerative diseases information
Field of study
This article needs more reliable medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Find sources: "Epigenetics of neurodegenerative diseases" – news · newspapers · books · scholar · JSTOR(May 2015)
Para-sagittal MRI of the head in a patient with benign familial macrocephaly
Neurodegenerative diseases are a heterogeneous group of complex disorders linked by the degeneration of neurons in either the peripheral nervous system or the central nervous system. Their underlying causes are extremely variable and complicated by various genetic and/or environmental factors. These diseases cause progressive deterioration of the neuron resulting in decreased signal transduction and in some cases even neuronal death. Peripheral nervous system diseases may be further categorized by the type of nerve cell (motor, sensory, or both) affected by the disorder. Effective treatment of these diseases is often prevented by lack of understanding of the underlying molecular and genetic pathology. Epigenetic therapy is being investigated as a method of correcting the expression levels of misregulated genes in neurodegenerative diseases.
Neurodengenerative diseases of motor neurons can cause degeneration of motor neurons involved in voluntary muscle control such as muscle contraction and relaxation. This article will cover the epigenetics and treatment of amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). See the Motor Neuron Fact Sheet[1] for details regarding other motor neuron diseases. Neurodegenerative diseases of the central nervous system can affect the brain and spinal cord. This article will cover the epigenetics and treatment of Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD). These diseases are characterized by chronic and progressive neuronal dysfunction, sometimes leading to behavioral abnormalities (as with PD), and, ultimately, neuronal death, resulting in dementia.
Neurodegenerative diseases of sensory neurons can cause degeneration of sensory neurons involved in transmitting sensory information such as hearing and seeing. The main group of sensory neuron diseases are hereditary sensory and autonomic neuropathies (HSAN) such as HSAN I, HSAN II, and Charcot-Marie-Tooth Type 2B (CMT2B).[2][3] Though some sensory neuron diseases are recognized as neurodegenerative, epigenetic factors have not yet been clarified in the molecular pathology.
^"Motor Neuron Diseases Fact Sheet: National Institute of Neurological Disorders and Stroke (NINDS)". Archived from the original on 2014-04-13. Retrieved 2019-08-09.
^Online Mendelian Inheritance in Man (OMIM): 600882 Charcot-Marie-Tooth Disease, Axonal, Type 2B; CMT2B - 600882
^Sghirlanzoni A, Pareyson D, Lauria G (June 2005). "Sensory neuron diseases". review. The Lancet. Neurology. 4 (6): 349–61. doi:10.1016/S1474-4422(05)70096-X. PMID 15907739. S2CID 35053543.
and 27 Related for: Epigenetics of neurodegenerative diseases information
neuron diseases. Neurodegenerativediseasesof the central nervous system can affect the brain and spinal cord. This article will cover the epigenetics and...
are mediated by erroneous epigenetic mechanisms. Neurodegenerativediseases include Huntington's disease and Alzheimer's disease. Neuroimmunological research...
Liver disease, or hepatic disease, is any of many diseasesof the liver. If long-lasting it is termed chronic liver disease. Although the diseases differ...
development, and the molecular basis for neuroplasticity and neurodegenerativediseases. As with molecular biology, molecular neuroscience is a relatively...
known as amyloidosis, and may play a role in some neurodegenerativediseases. Some of these diseases are mainly sporadic and only a few cases are familial...
response. Epigeneticsof autoimmune disorders List of autoimmune diseases "Autoimmune diseases". Office on Women's Health. U.S. Department of Health and...
Epigenetic regulation of neurogenesis is the role that epigenetics (hertitable characteristics that do not involve changes in DNA sequence) plays in the...
an emphasis on epigenetic causes of adult chronic non-communicable diseases. As well as physical human disease, the psychopathology of the foetus can...
Behavioral epigenetics is the field of study examining the role ofepigenetics in shaping animal and human behavior. It seeks to explain how nurture shapes...
Campbell A (2004). "Inflammation, NeurodegenerativeDiseases, and Environmental Exposures". Annals of the New York Academy of Sciences. 1035 (1): 117–132....
spongiform encephalopathies (TSEs) that are transmissible, fatal neurodegenerativediseases in humans and animals. The proteins may misfold sporadically,...
produce therapeutics to combat cancer and other diseases, such as infectious diseases and neurodegenerative disorders. Gene silencing is often considered...
Sleep epigenetics is the field of how epigenetics (heritable characteristics that do not involve changes in DNA sequence) affects sleep. Research in the...
repeat disorders, a subset of microsatellite expansion diseases (also known as repeat expansion disorders), are a set of over 30 genetic disorders caused...
impairment and increased propensity for developing neurodegenerativediseases, such as Alzheimer's disease. Elevated inflammatory markers seemed to accelerate...
Alzheimers, Epilepsy and Psychiatry. Neurodegenerativedisease List of central nervous system infections "Nervous System Diseases". Healthinsite.gov.au. Retrieved...
nutritional epigenetics. Each of these subcategories explain some aspect of how genes react to nutrients and express specific phenotypes, like disease risk....
identifying epigenetic mechanisms in health and disease states, and translating their findings into new treatments for cancer and neurodegenerativediseases. The...
(October 2017). "Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerativediseases". Journal of Neurochemistry. 143...
factor for a number of pollution-related diseases, including respiratory infections, heart disease, chronic obstructive pulmonary disease (COPD), stroke,...
shown methylation and other epigenetic regulation mechanisms to be associated with conditions of aging, neurodegenerativediseases, and intellectual disability...
and neurodegenerativediseases, it is important to describe and classify the types of changes that it entails. After a decade, the authors of the heavily...
progression ofneurodegenerativediseases such as Amyotrophic lateral sclerosis (ALS, also called Lou Gehrig's Disease), Alzheimer's disease, and Parkinson's...
Global Information
