Genetic marker at the lower tip of human X chromosome
The human X chromosome with Xq28 (green) located at the tip of the long arm of the chromosome. Studies of the X chromosome as well as the entire human genome have linked Xq28 to the heredity of homosexuality in human males.
Xq28 is a chromosome band and genetic marker situated at the tip of the X chromosome which has been studied since at least 1980.[1] The band contains three distinct regions, totaling about 8 Mbp of genetic information.[2] The marker came to the public eye in 1993 when studies by Dean Hamer and others indicated a link between the Xq28 marker and male sexual orientation.[3]
^Pai, GS; Sprenkle, JA; Do, TT; Mareni, CE; Migeon, BR (1980). "Localization of loci for hypoxanthine phosphoribosyltransferase and glucose-6-phosphate dehydrogenase and biochemical evidence of nonrandom X chromosome expression from studies of a human X-autosome translocation". Proceedings of the National Academy of Sciences of the United States of America. 77 (5): 2810–3. Bibcode:1980PNAS...77.2810P. doi:10.1073/pnas.77.5.2810. PMC 349494. PMID 6930669.
^De Sario, Albertina; Geigl, Eva-Maria; Palmieri, Giuseppe; d'Urso, Michele; Bernardi, Giorgio (1996). "A Compositional Map of Human Chromosome Band Xq28". Proceedings of the National Academy of Sciences of the United States of America. 93 (3): 1298–302. Bibcode:1996PNAS...93.1298D. doi:10.1073/pnas.93.3.1298. JSTOR 38791. PMC 40074. PMID 8577758.
^Hamer, D.; Hu, S; Magnuson, V.; Hu, N; Pattatucci, A. (1993). "A linkage between DNA markers on the X chromosome and male sexual orientation". Science. 261 (5119): 321–7. Bibcode:1993Sci...261..321H. doi:10.1126/science.8332896. PMID 8332896.
Xq28 is a chromosome band and genetic marker situated at the tip of the X chromosome which has been studied since at least 1980. The band contains three...
markers on the subtelomeric region of the long arm of the X chromosome, Xq28, providing statistically significant evidence for linkage to the sexual orientation...
scientists at Genentech. The gene for factor VIII is located on the X chromosome (Xq28). The gene for factor VIII presents an interesting primary structure, as...
biopsy. Molecular genetic testing of the NEMO IKBKG gene (chromosomal locus Xq28) reveals disease-causing mutations in about 80% of probands. Such testing...
MECP2 gene is located on the long (q) arm of the X chromosome in band 28 ("Xq28"), from base pair 152,808,110 to base pair 152,878,611. MECP2 is an important...
degeneration of the mitral valve is a genetic abnormality that is mapped to the Xq28 gene. And additionally to FLNA. Other genes that have been associated with...
genetic. He referenced the debunking of the research on the "gay gene" (Xq28), originally claimed by Dean Hamer. Naik argued that Hamer's assertion of...
after 'gay genes' finding". Of the tabloid headlines which commented on the Xq28 gene, the Mail's was criticised as "perhaps the most infamous and disturbing...
birth. MECP2 is found near the end of the long arm of the X chromosome at Xq28. An atypical form of RTT, characterized by infantile spasms or early onset...
Basepair start Basepair stop Band PAR1 X 10,001 2,781,479 Xp22 Y 10,001 2,781,479 Yp11 PAR2 X 155,701,383 156,030,895 Xq28 Y 56,887,903 57,217,415 Yq12...
mutations or deletions of the FAM58A gene, which is located on chromosome Xq28. This gene encodes Cyclin M, a Cyclin-dependent kinase 10 (CDK10) binding...
activates NF-κB. The human gene for IKBKG is located on the chromosome band Xq28. Multiple transcript variants encoding different isoforms have been found...
an X-linked disorder caused by mutation in SLC6A8. SLC6A8 is located at Xq28. Hemizygous males with CTD express speech and behavior abnormalities, intellectual...
early as two years of age. ALD is caused by mutations in ABCD1, located at Xq28 and demonstrates X-linked recessive inheritance. The gene ABCD1 encodes a...
March 2015. Marie Nielsen. "Nu er den officielle Pride sang 2012 her". www.xq28.dk. Retrieved 7 March 2015. "MrGay.dk finaleshow ved Copenhagen Pride på...
factor are associated with Rett syndrome, a neurodevelopmental disorder. Xq28 Diabetes A rare form of diabetes called MODY (Maturity onset diabetes of...
transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis...
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