PELI2 information

PELI2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3EGA, 3EGB
Identifiers
Aliases	PELI2, pellino E3 ubiquitin protein ligase family member 2
External IDs	OMIM: 614798 MGI: 1891445 HomoloGene: 41431 GeneCards: PELI2
Gene location (Human)
Chr.	Chromosome 14 (human)
End	56,301,524 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	48,519,032 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; jejunal mucosa; ; monocyte; ; body of pancreas; ; metanephric glomerulus; ; blood; ; sural nerve; ; retinal pigment epithelium; ; kidney tubule;
	Top expressed in
	basilar part of occipital bone; ; spermatid; ; fibula; ; splanchnocranium; ; seminiferous tubule; ; spermatocyte; ; Meckel's cartilage; ; sciatic nerve; ; ascending aorta; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-ubiquitin ligase activity; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase activity;
Cellular component	cytosol;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein phosphorylation; protein ubiquitination; positive regulation of MAPK cascade; protein polyubiquitination; protein phosphorylation; immune response; Toll signaling pathway; interleukin-1-mediated signaling pathway; regulation of Toll signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57161
	93834
	ENSG00000139946
	ENSMUSG00000021846
	Q9HAT8
	Q8BST6
	NM_021255
	NM_033602
	NP_067078
	NP_291080
	Wikidata
View/Edit Human	View/Edit Mouse

Protein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139946 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021846 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–4. doi:10.1159/000056895. PMID 11306823. S2CID 83911010.
^ Strelow A, Kollewe C, Wesche H (Jul 2003). "Characterization of Pellino2, a substrate of IRAK1 and IRAK4". FEBS Lett. 547 (1–3): 157–61. doi:10.1016/S0014-5793(03)00697-5. PMID 12860405.
^ "Entrez Gene: PELI2 pellino homolog 2 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139946 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021846 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11306823-5] Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–4. doi:10.1159/000056895. PMID 11306823. S2CID 83911010.

[pmid12860405-6] Strelow A, Kollewe C, Wesche H (Jul 2003). "Characterization of Pellino2, a substrate of IRAK1 and IRAK4". FEBS Lett. 547 (1–3): 157–61. doi:10.1016/S0014-5793(03)00697-5. PMID 12860405.

[entrez-7] "Entrez Gene: PELI2 pellino homolog 2 (Drosophila)".

PELI2 information

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PELI2

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TMEM260