IKK2 information

IKBKB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KIK, 3BRT, 3BRV, 4E3C
Identifiers
Aliases	IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa B kinase subunit beta, IMD15A, IMD15B
External IDs	OMIM: 603258 MGI: 1338071 HomoloGene: 7782 GeneCards: IKBKB
Gene location (Human)
Chr.	Chromosome 8 (human)
End	42,332,460 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	23,196,605 bp
RNA expression pattern
	Top expressed in
	spleen; ; right lobe of thyroid gland; ; right uterine tube; ; skin of abdomen; ; minor salivary glands; ; left lobe of thyroid gland; ; thymus; ; vagina; ; upper lobe of left lung; ; lymph node;
	Top expressed in
	blood; ; Paneth cell; ; crypt of lieberkuhn of small intestine; ; hair follicle; ; molar; ; medullary collecting duct; ; superior cervical ganglion; ; spleen; ; left lobe of liver; ; urothelium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; IkappaB kinase activity; nucleotide binding; protein homodimerization activity; scaffold protein binding; kinase activity; protein binding; ATP binding; protein kinase binding; protein heterodimerization activity; protein serine/threonine kinase activity; identical protein binding;
Cellular component	membrane; membrane raft; CD40 receptor complex; cytoplasmic side of plasma membrane; nucleus; IkappaB kinase complex; cytoplasm; cytosol;
Biological process	phosphorylation; regulation of tumor necrosis factor-mediated signaling pathway; cellular response to tumor necrosis factor; response to virus; regulation of phosphorylation; negative regulation of apoptotic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; Fc-epsilon receptor signaling pathway; positive regulation of transcription, DNA-templated; protein phosphorylation; negative regulation of bicellular tight junction assembly; stress-activated MAPK cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of myosin-light-chain-phosphatase activity; innate immune response; inflammatory response; I-kappaB kinase/NF-kappaB signaling; cortical actin cytoskeleton organization; positive regulation of transcription by RNA polymerase II; regulation of establishment of endothelial barrier; I-kappaB phosphorylation; tumor necrosis factor-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; anatomical structure morphogenesis; protein localization to plasma membrane; MyD88-independent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; interleukin-1-mediated signaling pathway; viral process;
	Sources:Amigo / QuickGO
Orthologs
	3551
	16150
	ENSG00000104365
	ENSMUSG00000031537
	O14920
	O88351
	NM_001190720; NM_001190721; NM_001190722; NM_001242778; NM_001556
	NM_001159774; NM_010546
	NP_001177649; NP_001229707; NP_001547
	NP_001153246; NP_034676
	Wikidata
View/Edit Human	View/Edit Mouse

IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104365 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031537 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104365 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031537 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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