positive regulation of interferon-gamma-mediated signaling pathway
positive regulation of humoral immune response mediated by circulating immunoglobulin
viral process
positive regulation of response to interferon-gamma
receptor-mediated endocytosis
hemoglobin metabolic process
heme transport
cellular iron ion homeostasis
heme metabolic process
positive regulation of tyrosine phosphorylation of STAT protein
transport
proteolysis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3263
15458
Ensembl
ENSG00000110169
ENSMUSG00000030895
UniProt
P02790
Q91X72
RefSeq (mRNA)
NM_000613
NM_017371
RefSeq (protein)
NP_000604
NP_059067
Location (UCSC)
Chr 11: 6.43 – 6.44 Mb
Chr 7: 105.24 – 105.25 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Hemopexin (or haemopexin; Hpx; Hx), also known as beta-1B-glycoprotein, is a glycoprotein that in humans is encoded by the HPX gene[5][6][7] and belongs to the hemopexin family of proteins.[8] Hemopexin is the plasma protein with the highest binding affinity for heme.[9]
Hemoglobin itself circulating alone in the blood plasma (called free hemoglobin, as opposed to the hemoglobin situated in and circulating with the red blood cell.) will soon be oxidized into met-hemoglobin which then further disassociates into free heme along with globin chain. The free heme will then be oxidized into free met-heme and sooner or later the hemopexin will come to bind free met-heme together, forming a complex of met-heme and hemopexin, continuing their journey in the circulation until reaching a receptor, such as LRP1, on hepatocytes or macrophages within the spleen, liver and bone marrow.[10]
Hemopexin's arrival and subsequent binding to the free heme not only prevent heme's pro-oxidant and pro-inflammatory effects but also promotes free heme's detoxification.[10]
Hemopexin is different from haptoglobin, the latter always binds to free hemoglobin.[11][10] (See Haptoglobin § Differentiation with hemopexin)
^ abcGRCh38: Ensembl release 89: ENSG00000110169 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030895 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: HPX hemopexin".
^Altruda F, Poli V, Restagno G, Silengo L (1988). "Structure of the human hemopexin gene and evidence for intron-mediated evolution". Journal of Molecular Evolution. 27 (2): 102–8. Bibcode:1988JMolE..27..102A. doi:10.1007/BF02138368. PMID 2842511. S2CID 11271490.
^Altruda F, Poli V, Restagno G, Argos P, Cortese R, Silengo L (June 1985). "The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology". Nucleic Acids Research. 13 (11): 3841–59. doi:10.1093/nar/13.11.3841. PMC 341281. PMID 2989777.
^Bode W (June 1995). "A helping hand for collagenases: the haemopexin-like domain". Structure. 3 (6): 527–30. doi:10.1016/s0969-2126(01)00185-x. PMID 8590012.
^Tolosano E, Altruda F (April 2002). "Hemopexin: structure, function, and regulation". DNA and Cell Biology. 21 (4): 297–306. doi:10.1089/104454902753759717. PMID 12042069.
Hemopexin (or haemopexin; Hpx; Hx), also known as beta-1B-glycoprotein, is a glycoprotein that in humans is encoded by the HPX gene and belongs to the...
thereby inhibits its deleterious oxidative activity. Compared to Hp, hemopexin binds to free heme. The haptoglobin-hemoglobin complex will then be removed...
The C-terminal domain has structural similarities to the serum protein hemopexin. It has a four-bladed β-propeller structure. β-Propeller structures provide...
The hemopexin family is a family of evolutionarily related proteins. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family...
time, hemopexin, another plasma glycoprotein come to bind with heme with its privilege of high heme affinity, forming a complex of heme-hemopexin, which...
promoting peroxidative reactions and activation of inflammatory cascades. Hemopexin (Hx) is another plasma glycoprotein able to bind heme with high affinity...
bilirubin and depletion of plasma proteins, such as albumin, haptoglobin, and hemopexin, which may lead to jaundice. It may also lead to increased levels of the...
three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain. Proteins of the matrix metalloproteinase (MMP) family are...
haptoglobin (Hp), transferrin (Tf), ceruloplasmin (Cp), fibrinogen (Fg), and hemopexin (Hpx). Since those are Acute-phase proteins, a positive Rivalta's test...
methemoglobin from which the heme moiety is bound to hemopexin or to albumin, and both heme-hemopexin and heme-bound albumin are internalized by hepatocytes...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein...
vascular injury. Several proteins in human blood bind to hemin, such as hemopexin and serum albumin. A lyophilised form of hemin is used as a pharmacological...
Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is synthesized and excreted by the liver, and abundantly found in serum, the extracellular...
overwhelming hemoglobin binding proteins such as albumin, haptoglobin, and hemopexin, with the excess free hemoglobin leading to renal vasoconstriction (via...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein...
not. Colostrum also has antioxidant components, such as lactoferrin and hemopexin, which binds free heme in the body. The Isle of Man had a local delicacy...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein...
and release the heme group that is able to bind to either albumin or hemopexin. The heme is ultimately converted to bilirubin and removed in stool and...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein...
Cardiotoxicity in patients and mice can be mitigated by circulating hemopexin. Anthracycline-mediated cardiotoxicity is dose-dependent and cumulative...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein...
progesterone Haptoglobin, carries free hemoglobin released from erythrocytes Hemopexin, carries free heme released from hemoglobin IGF binding protein, carries...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein...
ppat.1003317. PMC 3630162. PMID 23637606. Smith A, McCulloh RJ (2015). "Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders"...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein...
enzyme. The hemopexin-like domain of MMPs is highly conserved and shows sequence similarity to the plasma protein, hemopexin. The hemopexin-like domain...
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