negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
ossification
negative regulation of intrinsic apoptotic signaling pathway
ephrin receptor signaling pathway
extracellular matrix disassembly
negative regulation of apoptotic process
proteolysis
macrophage differentiation
positive regulation of keratinocyte migration
positive regulation of apoptotic process
collagen catabolic process
positive regulation of release of cytochrome c from mitochondria
positive regulation of receptor binding
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
embryo implantation
leukocyte migration
positive regulation of vascular associated smooth muscle cell proliferation
extracellular matrix organization
positive regulation of cell migration
neutrophil degranulation
cellular response to reactive oxygen species
cellular response to cadmium ion
cytokine-mediated signaling pathway
regulation of neuroinflammatory response
negative regulation of epithelial cell differentiation involved in kidney development
response to amyloid-beta
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4318
17395
Ensembl
ENSG00000100985
ENSMUSG00000017737
UniProt
P14780
P41245
RefSeq (mRNA)
NM_004994
NM_013599
RefSeq (protein)
NP_004985
NP_038627
Location (UCSC)
Chr 20: 46.01 – 46.02 Mb
Chr 2: 164.78 – 164.8 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene[5] encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000100985 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000017737 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)".
^Nagase H, Woessner JF (July 1999). "Matrix metalloproteinases". The Journal of Biological Chemistry. 274 (31): 21491–4. doi:10.1074/jbc.274.31.21491. PMID 10419448.
family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with...
concentrations show a significant increased cytotoxic activity and suppress COX-2 and MMP9 gene expression in both cell culture and colon tissue, suggest the anti-inflammatory...
of growth factors and are required for tumor metastasis and angiogenesis. MMP9 is associated with the bone microenvironment. It is expressed by osteoclasts...
of ages 76 to 80 years. Epitalon appears to inhibit the synthesis of the MMP9 protein in vitro in aging skin fibroblasts. An in vivo study in aging mice...
collagen synthesis and fibrosis of the heart. Increase expression of MMP1 and MMP9 led to degradation of collagen fibres, and subsequently dilatation of the...
to aortic dissection and aneurysm. However, other studies have also shown MMP9 involvement with no differences in TIMP expression. The size of the proximal...
active site zinc. Examples of enzymes that ilomastat inhibit include rabbit MMP9, thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase...
against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration into tumours...
expressed are matrix metalloproteinases MMP2 and MMP9. Additionally, gelatinases A (MMP2) and B (MMP9) have been proven to assist in developing new blood...
Oi Y, Milewicz DM (*Authors contribution equal). Association of MMP2 and MMP9 polymorphisms with intracranial aneurysms. J Neurosurg. 105(3):418-23, 2006...
angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). MTDH acts as an oncogene in melanoma, malignant glioma, breast cancer and...
This resulted in cells being promoted to enter S phase more rapidly ROCK-1 MMP9: necessary for ECM regulation FMNL3: a Formin downstream target, which is...
MMP7 has a shallow hydrophobic substrate-binding pocket. In contrast to MMP9 which has the longest hinge, MMP7 lacks hemopexin and does not have a hinge...
phosphorylation. This can then trigger expression of matrix metalloproteinase 9 (MMP9). MMP9 can degrade proteins in the extracellular matrix, which aids in the priming...
Ronkainen A, Juvonen T, Kuivaniemi H (Nov 1999). "Genetic analysis of MMP3, MMP9, and PAI-1 in Finnish patients with abdominal aortic or intracranial aneurysms"...
angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). Along with its main oncogene function in hepatocellular carcinoma (HCC)...
induction of prometastatic and angiogenic factors like CCL2, Cox-2, MMP2, MMP9 and VEGF. Furthermore mS100a7a15 recruits tumor-associated-macrophages (TAM)...
(February 2011). "Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic...