Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases;[1] other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.[2]
Collectively, these enzymes are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine inactivation.[3] MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
They were first described in vertebrates in 1962,[4] including humans, but have since been found in invertebrates and plants. They are distinguished from other endopeptidases by their dependence on metal ions as cofactors, their ability to degrade extracellular matrix, and their specific evolutionary DNA sequence.
^Verma RP, Hansch C (March 2007). "Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs" (PDF). Bioorg. Med. Chem.15 (6): 2223–68. doi:10.1016/j.bmc.2007.01.011. PMID 17275314. Archived from the original (PDF) on 13 May 2015. Retrieved 21 October 2015.
^Matrix Metalloproteinases: Its implications in cardiovascular disorders
^Van Lint P, Libert C (December 2007). "Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation". J. Leukoc. Biol.82 (6): 1375–81. doi:10.1189/jlb.0607338. PMID 17709402.
^Gross, J.; Lapiere, C. M. (June 1962). "Collagenolytic activity in amphibian tissues: a tissue culture assay". Proceedings of the National Academy of Sciences. 48 (6): 1014–22. Bibcode:1962PNAS...48.1014G. doi:10.1073/pnas.48.6.1014. PMC 220898. PMID 13902219.
and 27 Related for: Matrix metalloproteinase information
Matrixmetalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing...
metalloendopeptidases include ADAM proteins and matrixmetalloproteinases, and M16 metalloproteinases such as Insulin Degrading Enzyme and Presequence...
72 kDa type IV collagenase also known as matrixmetalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The...
A matrixmetalloproteinase inhibitor (INN stem –mastat) inhibits matrixmetalloproteinases. Because they inhibit cell migration, they have antiangiogenic...
Matrixmetalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes...
in humans is encoded by the MMP13 gene. It is a member of the matrixmetalloproteinase (MMP) family. Like most MMPs, it is secreted as an inactive pro-form...
Plant matrixmetalloproteinases are metalloproteins and zinc enzymes found in plants. Matrixmetalloproteinases (MMPs) are zinc endopeptidases, commonly...
abnormalities. The matrixmetalloproteinases (MMPs) comprise a family of more than 20 zinc-dependent endopeptidases. The role of matrixmetalloproteinases (MMPs)...
Interstitial collagenase, also known as fibroblast collagenase and matrixmetalloproteinase-1 (MMP-1), is an enzyme that in humans is encoded by the MMP1 gene...
Stromelysin-1 also known as matrixmetalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster...
Matrilysin also known as matrixmetalloproteinase-7 (MMP-7), pump-1 protease (PUMP-1), or uterine metalloproteinase is an enzyme in humans that is encoded...
Matrixmetalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded...
tendon actively synthesize matrix components as well as enzymes such as matrixmetalloproteinases (MMPs) can degrade the matrix. Tendons are capable of healing...
Basigin (BSG) also known as extracellular matrixmetalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147) is a protein that in humans...
role in degradation of extracellular matrix and tissue remodeling. Gelatinases are a type of matrixmetalloproteinase (MMP), a family of enzymes that depend...
Matrixmetalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene. Proteins of the matrixmetalloproteinase (MMP) family are involved...
Tissue inhibitors of metalloproteinases (TIMPs) are specific endogenous protease inhibitors to the matrixmetalloproteinases. There are four TIMPs; TIMP1...
proteases including matrixmetalloproteinases (MMPs), a disintegrin and metalloproteinase domain (ADAM), a disintegrin and metalloproteinase domain with throbospondin...
Metalloprotease inhibitors are cellular inhibitors of the Matrixmetalloproteinases (MMPs). MMPs belong to a family of zinc-dependent neutral endopeptidases...
multiprocessing (SMP) computer systems Measure Map Pro format, a GIS format Matrixmetalloproteinase enzymes Methuselah Mouse Prize, for research into slowing cellular...
Wells GM, Perry VH, Brown MC, Miller KM (2002). "Comparison of matrixmetalloproteinase expression during wallerian degeneration in the central and peripheral...
destruction of extracellular matrix by enzymes such as serine proteases, threonine proteases, and matrixmetalloproteinases. The stiffness and elasticity...
natural inhibitors of the matrixmetalloproteinases (MMP), a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory...
Neutrophil collagenase, also known as matrixmetalloproteinase-8 (MMP-8) or PMNL collagenase (MNL-CL), is a collagen cleaving enzyme which is present in...