protein serine/threonine kinase activator activity
metal ion binding
peptidase activity
protein binding
serine-type peptidase activity
serine-type endopeptidase activity
hydrolase activity
lipopolysaccharide binding
cysteine-type endopeptidase inhibitor activity
Cellular component
cytoplasm
secretory granule
extracellular region
cell surface
specific granule
phagocytic vesicle lumen
extracellular exosome
nucleus
extracellular space
specific granule lumen
tertiary granule lumen
protein-containing complex
Biological process
positive regulation of osteoblast proliferation
regulation of transcription, DNA-templated
positive regulation of chondrocyte proliferation
negative regulation of osteoclast development
ossification
regulation of tumor necrosis factor production
negative regulation of viral process
immune system process
negative regulation of ATP-dependent activity
antibacterial humoral response
bone morphogenesis
iron ion homeostasis
positive regulation of bone mineralization involved in bone maturation
negative regulation of apoptotic process
ion transport
transcription, DNA-templated
proteolysis
positive regulation of protein serine/threonine kinase activity
negative regulation of single-species biofilm formation in or on host organism
negative regulation by host of viral process
negative regulation of lipopolysaccharide-mediated signaling pathway
regulation of cytokine production
negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
retina homeostasis
negative regulation of viral genome replication
innate immune response in mucosa
positive regulation of osteoblast differentiation
humoral immune response
defense response to bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of toll-like receptor 4 signaling pathway
siderophore-dependent iron import into cell
antimicrobial humoral response
neutrophil degranulation
innate immune response
negative regulation of membrane potential
antimicrobial humoral immune response mediated by antimicrobial peptide
negative regulation of cysteine-type endopeptidase activity
transport
antifungal humoral response
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4057
17002
Ensembl
ENSG00000012223
ENSMUSG00000032496
UniProt
P02788
P08071
RefSeq (mRNA)
NM_002343 NM_001199149 NM_001321121 NM_001321122
NM_008522
RefSeq (protein)
NP_001186078 NP_001308050 NP_001308051 NP_002334
NP_032548
Location (UCSC)
Chr 3: 46.44 – 46.49 Mb
Chr 9: 110.85 – 110.87 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. Lactoferrin is a globular glycoprotein with a molecular mass of about 80 kDa that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. Lactoferrin is also present in secondary granules of PMNs and is secreted by some acinar cells. Lactoferrin can be purified from milk or produced recombinantly. Human colostrum ("first milk") has the highest concentration, followed by human milk, then cow milk (150 mg/L).[5]
Lactoferrin is one of the components of the immune system of the body; it has antimicrobial activity (bacteriocide, fungicide) and is part of the innate defense, mainly at mucoses.[5] It is constantly produced and released into saliva, tears, as well as seminal and vaginal fluid.[6] Lactoferrin provides antibacterial activity to human infants.[7][8] Lactoferrin interacts with DNA and RNA, polysaccharides and heparin, and shows some of its biological functions in complexes with these ligands.
Lactoferrin supplements reduce the risk of respiratory tract infections, based on a recent meta-analysis of randomized controlled trials.[9] As with any supplements sold online, quality may be an issue because nutritional supplement production quality controls are not subject to the same strict regulatory process as medicines.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000012223 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032496 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abSánchez L, Calvo M, Brock JH (May 1992). "Biological role of lactoferrin". Archives of Disease in Childhood. 67 (5): 657–61. doi:10.1136/adc.67.5.657. PMC 1793702. PMID 1599309.
^Ashraf MF, Zubair D, Arain MA (2023). "Nutraceutical and Health-Promoting Potential of Lactoferrin, an Iron-Binding Protein in Human and Animal: Current Knowledge". Biological Trace Element Research. 202 (1): 56–72. doi:10.1007/s12011-023-03658-4. PMC 10104436. PMID 37059920.
^Levin RE, Kalidas S, Gopinadhan P, Pometto A (2006). Food biotechnology. Boca Raton, FL: CRC/Taylor & Francis. p. 1028. ISBN 978-0-8247-5329-0.
^Pursel VG (1998). "Modification of Production Traits". In Clark AJ (ed.). Animal Breeding: Technology for the 21st Century (Modern Genetics). Boca Raton: CRC. p. 191. ISBN 978-90-5702-292-0.
^Ali AS, Hasan SS, Kow CS, Merchant HA (October 2021). "Lactoferrin reduces the risk of respiratory tract infections: A meta-analysis of randomized controlled trials" (PDF). Clinical Nutrition ESPEN. 45: 26–32. doi:10.1016/j.clnesp.2021.08.019. PMID 34620326. S2CID 238475090.
^"Lactoferrin supplements could aid in the recovery of COVID19 & other Respiratory Tract Infections". EurekAlert!. Retrieved 2022-02-18.
Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. Lactoferrin is a globular glycoprotein...
bind lactoferrin that is released together with the contents of neutrophils during inflammation and bleeding in periodontitis patients. Lactoferrin inhibits...
also bear this coverage: lactoferrin, lactoperoxidase, lysozyme, rich proline polypeptide — PRP and alpha-lactalbumine. Lactoferrin has many properties that...
"Combined treatments of high-pressure with the lactoperoxidase system or lactoferrin on the inactivation of Listeria monocytogenes, Salmonella Enteritidis...
such as collagenase, gelatinase or serine proteases, myeloperoxidase, lactoferrin and antibiotic proteins. Degranulation of these into the phagosome, accompanied...
property of the lactoferrin protein present in the Vechur Cow milk is more than that of the antibiotic ampicillin. Although lactoferrin, present in the...
molecules active in antimicrobial protection such as lysozyme and lactoferrin. The lactoferrin content of donkey milk is intermediate between the lower values...
Between 15 and 20 percent of the protein content in human milk consists of lactoferrin that binds iron. As a comparison, in cow's milk, this is only 2 percent...
colostrum include the major components of the innate immune system, such as lactoferrin, lysozyme, lactoperoxidase, complement, and proline-rich polypeptides...
simplex virus and can transfer anti-microbial peptides cathelicidin and lactoferrin. In birds and mammals, mutalistic bacteria such as Lactobacillus have...
fertilizer. Ventria Bioscience has genetically modified rice to express lactoferrin and lysozyme which are proteins usually found in breast milk, and human...
known to contain lactoferrin, which protects the infant from infection caused by a wide range of pathogens. The amount of lactoferrin in breast milk increases...
use of certain chemicals that are part of standard wound care (e.g. lactoferrin or silver) may have interfered with bacteriophage viability. Shortly...
the innate immune system are eliminated by the adaptive immune system. Lactoferrin (LF) is a multifunctional protein which is an essential part of the respiratory...
formula, adult and early life nutrition products, ingredients such as lactoferrin and foodservice products such as UHT cream. Synlait has over 280 milk...
as a mechanical barrier and secondarily via the presence of lysozyme, lactoferrin and antimicrobial components in peptide layer. Moisturizing the stratum...
cataloged to possess immune-modulating capabilities include immunoglobulins, Lactoferrin, Lysozyme, oligosaccharides, lipids, cytokines, hormones, and growth...
Cholesterylester transfer protein Clusterin Colony-stimulating factor Hemopexin Lactoferrin Membrane glycoproteins Myelin protein zero Osteonectin Protein C Protein...
lysozymes), immunoglobulins (especially IgA), and glycoproteins such as lactoferrin and mucins, which are produced by goblet cells in the mucous membranes...
contains less iron than formula, but the iron is more bioavailable as lactoferrin, which carries more safety for mothers and children than ferrous sulphate...
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