synovial membrane of articular capsule of synovial joint
minor salivary glands
islet of Langerhans
stromal cell of endometrium
testicle
Top expressed in
lactiferous gland
ankle joint
conjunctival fornix
skin of external ear
tunica adventitia of aorta
subcutaneous adipose tissue
tunica media of zone of aorta
endothelial cell of lymphatic vessel
right lung lobe
carotid body
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
zinc ion binding
peptidase activity
endopeptidase activity
metalloendopeptidase activity
protein binding
hydrolase activity
metal ion binding
serine-type endopeptidase activity
metallopeptidase activity
Cellular component
extracellular matrix
extracellular region
extracellular space
Biological process
collagen catabolic process
cellular response to nitric oxide
negative regulation of hydrogen peroxide metabolic process
extracellular matrix disassembly
proteolysis
positive regulation of protein oligomerization
positive regulation of oxidative stress-induced cell death
cytokine-mediated signaling pathway
response to hypoxia
regulation of cell migration
regulation of neuroinflammatory response
extracellular matrix organization
response to amyloid-beta
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4314
17392
Ensembl
ENSG00000149968
ENSMUSG00000043613
UniProt
P08254
P28862
RefSeq (mRNA)
NM_002422
NM_010809
RefSeq (protein)
NP_002413
NP_034939
Location (UCSC)
Chr 11: 102.84 – 102.84 Mb
Chr 9: 7.45 – 7.46 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Stromelysin 1
Identifiers
EC no.
3.4.24.17
CAS no.
79955-99-0
Databases
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
RCSB PDB PDBe PDBsum
Search
PMC
articles
PubMed
articles
NCBI
proteins
Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[5] MMP-3 has an estimated molecular weight of 54 kDa.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000149968 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000043613 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome...
gelatinase secreted Substrates include Gelatin, Col I, II, III, IV, Vii, X MMP3 Stromelysin 1 CHDS6, MMP-3, SL-1, STMY, STMY1, STR1 secreted Substrates include...
of life' inlay up the neck and finished in antique sunburst, an MMP2 and MMP3 available in "transparent cannon blue" and "brown burst" finishes. These...
collagen (sp1 site), type IX collagen, vitamin D receptor, aggrecan, asporin, MMP3, interleukin-1, and interleukin-6 polymorphisms. Mutation in genes – such...
collagen (sp1 site), type IX collagen, vitamin D receptor, aggrecan, asporin, MMP3, interleukin-1, and interleukin-6 polymorphisms. Mutation in genes – such...
(July 2009). "Polymorphism of matrix metalloproteinase genes ( MMP1 and MMP3 ) in patients with varicose veins". Clinical and Experimental Dermatology...
cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. GRCh38: Ensembl release 89: ENSG00000156103 – Ensembl, May 2017...
concerning dementia. This funding goes towards Spillantini's studies on MMP3, an enzyme whose activity is potentially connected to dementia and other...
invasiveness. SIM2s represses the actions of the matrix metalloprotease-3 gene (MMP3) which include cell migration, cancer progression, and epithelial to mesenchymal...
bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that ZNF384 may be part of a general...
Global Information
