Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP).[1] A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase.
^Cherfils J, Zeghouf M (January 2013). "Regulation of small GTPases by GEFs, GAPs, and GDIs". Physiological Reviews. 93 (1): 269–309. doi:10.1152/physrev.00003.2012. PMID 23303910.
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Guaninenucleotideexchangefactors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate...
membrane-associated G-protein known as Ras. The guaninenucleotideexchangefactor mediates Ras activation through the GDP-GTP exchange process. The active Ras protein...
G proteins, also known as guaninenucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in...
S2CID 2418867. Bryan BA, Cai Y, Liu M (2006). "The Rho-family guaninenucleotideexchangefactor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth"...
molecular biology, the EF1 guaninenucleotideexchange domain is a protein domain found in the beta and delta chains of elongation factors from eukaryotes and...
Rho guaninenucleotideexchangefactor 7 is a protein that in humans is encoded by the ARHGEF7 gene. ARHGEF7 is commonly known as the p21-activated protein...
ARHGEF11, and ARHGEF12. These ARHGEF proteins function as guaninenucleotideexchangefactors for the Rho small GTPases to regulate the actin cytoskeleton...
The human ARHGEF10 gene encodes the protein Rho guaninenucleotideexchangefactor 10. Rho GTPases play a fundamental role in numerous cellular processes...
Rho guaninenucleotideexchangefactor 5 is a protein that in humans is encoded by the ARHGEF5 gene. Rho GTPases play a fundamental role in numerous cellular...
ARHGEF11, and ARHGEF12. These ARHGEF proteins function as guaninenucleotideexchangefactors for the Rho small GTPases to regulate the actin cytoskeleton...
Hansen SH, Casanova JE (1998). "ARNO is a guaninenucleotideexchangefactor for ADP-ribosylation factor 6". J. Biol. Chem. 273 (1): 23–7. doi:10.1074/jbc...
bind to a nuclear transport factor, where a GuanineNucleotideExchangeFactor Protein can come to catalyze the exchange of GTP for GDP. We also see GTP...
Rap guaninenucleotideexchangefactor (GEF) 4 (RAPGEF4), also known as exchange protein directly activated by cAMP 2 (EPAC2) is a protein that in humans...
(about 45-60 nucleotides per second).[citation needed] In eukaryotes the rate is about two amino acids per second (about 6 nucleotides read per second)...
Brefeldin A-inhibited guaninenucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene. ADP-ribosylation factors (ARFs) play an...
a GPCR, the GPCR acquires GEF (guaninenucleotideexchangefactor) ability, which activates the G-protein by exchanging the GDP on the alpha subunit to...
complex. Finally, with the help of the guaninenucleotideexchangefactor (GEF) eIF2B, the GDP in eIF2 is exchanged for a GTP and the ternary complex reforms...
Guaninenucleotideexchangefactor MSS4 is a protein that in humans is encoded by the RABIF gene. The Sec4/Rab-related small GTP-binding proteins are involved...
Guaninenucleotide-binding protein G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene. Together with GNA11 (its paralogue), it...
protein that in humans is encoded by the SOS1 gene. SOS1 is a guaninenucleotideexchangefactor (GEF) which interacts with Ras proteins to phosphorylate GDP...
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