regulation of small GTPase mediated signal transduction
positive regulation of epidermal growth factor receptor signaling pathway
leukocyte migration
signal transduction
positive regulation of GTPase activity
small GTPase mediated signal transduction
ERBB2 signaling pathway
G protein-coupled receptor signaling pathway
cytokine-mediated signaling pathway
neurotrophin TRK receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6654
20662
Ensembl
ENSG00000115904
ENSMUSG00000024241
UniProt
Q07889
Q62245
RefSeq (mRNA)
NM_005633 NM_001382394 NM_001382395
NM_009231
RefSeq (protein)
NP_005624 NP_001369323 NP_001369324
NP_033257
Location (UCSC)
Chr 2: 38.96 – 39.12 Mb
Chr 17: 80.7 – 80.79 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000115904 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024241 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Webb GC, Jenkins NA, Largaespada DA, Copeland NG, Fernandez CS, Bowtell DD (October 1993). "Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively". Genomics. 18 (1): 14–19. doi:10.1006/geno.1993.1421. PMID 8276400.
^Xiao S, Wang X, Qu B, Yang M, Liu G, Bu L, et al. (September 2000). "Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on 2p21". Genomics. 68 (3): 247–252. doi:10.1006/geno.2000.6285. PMID 10995566.
sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene. SOS1 is a guanine nucleotide exchange factor (GEF) which interacts with...
each ommatidium fails to form. Similarly, the mammalian orthologues of Sos, SOS1 and SOS2, function downstream of many growth factor and adhesion receptors...
key ones being PTPN11 accounting for 50% of genetically diagnosed cases, SOS1 responsible for 10-13% of cases, and RAF1 or RIT1 - each contributing to...
pathway at or above the level of SOS1. SOS1 in turn regulates the activities of RAS, RAF, MEK, ERK, and p90RSK. SOS1 has been demonstrated to be a target...
(SOS1) is an important GEF in the cell growth-regulatory MAPK/ERK pathway. SOS1 binds GRB2 at the plasma membrane after EGF receptor activation. SOS1 activates...
phosphorylation of SOS1 (Son of Sevenless) at Serines 1134 and 1161 creates 14-3-3 docking site. This interaction of phospho SOS1 and 14-3-3 negatively...
small G proteins that activate guanine nucleotide exchange factors such as SOS1. Once activated, these exchange factors can activate more small G proteins...
proteins of the Guanine Nucleotide Exchange Factor (GEF) class (such as SOS1), which forces the release of bound nucleotide (GDP). Subsequently, KRAS...
then activates SOS1. Finally, this causes the extrusion of any extra Sodium to the outside through Na+/H+ antiporter which is near SOS1. The SOS2-SOS3...
1701963 is an investigational drug that blocks KRAS activation by binding to SOS1 proteins. The drug is thought to be effective in cancers with a KRAS mutation...
of conformations when binding GTP or GDP or no nucleotide (when bound to SOS1, which releases the nucleotide). Ras also binds a magnesium ion which helps...
proteins of the Guanine Nucleotide Exchange Factor (GEF) class, for example SOS1, which forces the release of bound nucleotide. Subsequently, GTP present...
"Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and...
ABI1 gene. Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to...
proteins SPRY1, SPRY2, SPRY3, and/or SPRY4 which in turn interact with GRB2, SOS1, and/or c-Raf to reduce or inhibit further cell stimulation by activated...
immunity. MUC1 has been shown to interact with: CTNND1, ERBB2, GRB2, JUP, and SOS1. The ability of chemotherapeutic drugs to access the cancer cells is inhibited...
C (August 1999). "M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative...
There are two sorts of Special Ordered Sets: Special Ordered Sets of type 1 (SOS1 or S1): are a set of variables, at most one of which can take a non-zero...
protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. GRAP has...
Global Information
