positive regulation of DNA-binding transcription factor activity
positive regulation of podosome assembly
myeloid dendritic cell chemotaxis
positive regulation of GTPase activity
positive regulation of protein import
regulation of ERK1 and ERK2 cascade
regulation of Rho protein signal transduction
regulation of cytoskeleton organization
actin cytoskeleton organization
positive regulation of stress fiber assembly
positive regulation of apoptotic process
regulation of small GTPase mediated signal transduction
G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7984
54324
Ensembl
ENSG00000050327
ENSMUSG00000033542
UniProt
Q12774
E9Q7D5
RefSeq (mRNA)
NM_001002861 NM_005435
NM_133674
RefSeq (protein)
NP_005426
NP_598435
Location (UCSC)
Chr 7: 144.36 – 144.38 Mb
Chr 6: 43.24 – 43.27 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.[5][6][7]
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000050327 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000033542 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T (Apr 1994). "Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins". Oncogene. 9 (4): 1057–63. PMID 8134109.
^Takai S, Chan AM, Yamada K, Miki T (Oct 1995). "Assignment of the human TIM proto-oncogene to 7q33→q35". Cancer Genet Cytogenet. 83 (1): 87–9. doi:10.1016/S0165-4608(95)00017-8. PMID 7656213.
nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene. Rho GTPases play a fundamental role in numerous cellular processes...