positive regulation of actin filament polymerization
ruffle organization
small GTPase mediated signal transduction
regulation of Rac protein signal transduction
nervous system development
negative regulation of dendrite development
cell division
negative regulation of receptor-mediated endocytosis
cell adhesion
protein localization to cell surface
protein transport
protein localization to endosome
cell cycle
liver development
myeloid cell apoptotic process
cortical actin cytoskeleton organization
vesicle-mediated transport
regulation of dendritic spine development
hepatocyte apoptotic process
transport
positive regulation of protein localization to plasma membrane
intracellular protein transport
regulation of neuron projection development
endocytic recycling
synaptic vesicle endocytosis
positive regulation of keratinocyte migration
ruffle assembly
maintenance of postsynaptic density structure
positive regulation of adherens junction organization
regulation of presynapse assembly
cellular response to nerve growth factor stimulus
negative regulation of protein localization to cell surface
positive regulation of protein secretion
positive regulation of protein homodimerization activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
382
11845
Ensembl
ENSG00000165527
ENSMUSG00000044147
UniProt
P62330
P62331
RefSeq (mRNA)
NM_001663
NM_007481
RefSeq (protein)
NP_001654
NP_031507
Location (UCSC)
Chr 14: 49.89 – 49.9 Mb
Chr 12: 69.42 – 69.42 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.
^ abcGRCh38: Ensembl release 89: ENSG00000165527 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000044147 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that...
poorly or not at all to the GDP nucleotide. Structural studies of Arf1 and Arf6 have revealed that although these proteins feature the switch 1 and 2 conformational...
free to bind with a human partner protein called ARF6 (ADP-ribosylation factor 6); binding to Arf6 drives a change in the shape of CTA1 which exposes...
freed to bind with a human partner protein called ADP-ribosylation factor 6 (Arf6). Binding exposes its active site, allowing it to permanently ribosylate...
necessary for the pre-coupling. It has also been shown to interact with Arf6 and ARF1. Muscarinic acetylcholine receptor GRCh38: Ensembl release 89: ENSG00000133019...
large protein family of TRP ion channels. TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport...
component of the complex) and Arf small GTPases (such as ARF1, ARF5, and ARF6 ) or the similar protein ARL1, which causes dissociation of the CYFIP1-Nap1-Abi2...
GTPases ADP-ribosylation factor (ARF) 1 and ARF5 and weak activity towards ARF6. The encoded protein is believed to function as an ARF GAP that controls...
exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The CYTH4 and CYTH1 gene structures are very similar. GRCh38: Ensembl release...
epithelial cell surface polarity. EXOC5 has been shown to interact with Arf6. GRCh38: Ensembl release 89: ENSG00000070367 – Ensembl, May 2017 GRCm38:...
humans is encoded by the ARFIP2 gene. ARFIP2 has been shown to interact with Arf6, ARF3, ARF5 and RAC1. GRCh38: Ensembl release 89: ENSG00000132254 – Ensembl...
Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA (October 2000). "ACAPs are arf6 GTPase-activating proteins that function in the cell periphery". The Journal...
cytoskeleton remodeling through interacting with cytohesin-2 (ARNO) and Arf6. ALDOA is ubiquitously expressed in most tissues, though it is predominantly...
exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5. This activates the ADP-ribosylation...
infection. Amastigotes of L. donovani enter macrophages via a Rac1- and Arf6-dependent process, and are found in phagocytic vacuoles that interact with...
'KIAA1110', under which name it was found to act as a GEF for Arf1 but not Arf6. It is related to the other Arf-GEF protein IQSEC1. "www.genenames.org"....
class I (ARF1, ARF2, and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF5 gene...
"CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration". Exp. Cell Res. 318 (3): 228–37. doi:10.1016/j...
categorized as class I (ARF1 and ARF3), class II (ARF4 and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF4 gene...
and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this...
exchange factor for Rac/Cdc42, and GIT1, a GTPase activating protein for ARF6 implicated in receptor recycling and exocytosis. SCRIB is found in the cell...
Global Information
