adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of canonical Wnt signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2776
14682
Ensembl
ENSG00000156052
ENSMUSG00000024639
UniProt
P50148
P21279
RefSeq (mRNA)
NM_002072
NM_008139
RefSeq (protein)
NP_002063 NP_002063.2
NP_032165
Location (UCSC)
Chr 9: 77.72 – 78.03 Mb
Chr 19: 16.11 – 16.36 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Guanine nucleotide-binding protein G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene.[5] Together with GNA11 (its paralogue), it functions as a Gq alpha subunit.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000156052 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024639 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Dong Q, Shenker A, Way J, Haddad BR, Lin K, Hughes MR, McBride OW, Spiegel AM, Battey J (February 1997). "Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene". Genomics. 30 (3): 470–75. doi:10.1006/geno.1995.1267. PMID 8825633.
^139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11 at OMIM. Retrieved January 1, 2015.
protein G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene. Together with GNA11 (its paralogue), it functions as a Gq alpha subunit...
distinct proteins in the Gq alpha subunit family: Gαq is encoded by the gene GNAQ. Gα11 is encoded by the gene GNA11. Gα14 is encoded by the gene GNA14. Gα15...
endothelial cells. A study published in 2019 identified that somatic mutations in GNAQ and GNA11 genes are present in many cherry angiomas. These specific missense...
frequently harbor GNAQ/GNA11 mutations, a trait shared with blue nevi, nevus of Ota, and ocular melanosis. As seen in BRAF, mutations in GNAQ/GNA11 are early...
Sturge-Weber syndrome is caused by an activating somatic mutation in the GNAQ gene and it affects approximately 1 in 20,000–50,000 live births. The mutation...
deficits during treatment. Selumetinib has also been shown to inhibit growth of GNAQ mutated uveal melanoma cell lines. Furthermore, preliminary results suggest...
is a protein that in humans is encoded by the GNA11 gene. Together with GNAQ (its paralogue), it functions as a Gq alpha subunit. Gq alpha subunit GRCh38:...
in the GNAQ gene. Capillary malformations consist of endothelial cells that have a missense mutation in this gene at p.R183L and p.R183G. GNAQ gene encodes...
"Ultra-sensitive droplet digital PCR for detecting a low-prevalence somatic GNAQ mutation in Sturge-Weber syndrome". Scientific Reports. 6 (1): 22985. Bibcode:2016NatSR...
identified to be associated with metastasis in uveal melanomas. Moreover BAP1, GNAQ, GNA11, SF3B1 and EIF1AX gene alterations were shown to be in correlation...
000 live births and is caused by a somatic activating mutation in GNAQ. Normally, GNAQ is involved in cell growth signal transmission. It is classically...
are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the...
peptides CCG-4986 RGS4 has been shown to interact with: COPB2, ERBB3, and GNAQ. GRCh38: Ensembl release 89: ENSG00000117152 – Ensembl, May 2017 GRCm38:...
in the phototransduction cascade. RGS16 has been shown to interact with GNAQ and GNAI3. GRCh38: Ensembl release 89: ENSG00000143333 – Ensembl, May 2017...
encoded by the RIC8A gene. RIC8A has been shown to interact with GNAO1, GNA13, GNAQ, GNAS complex locus, GNAI2, GNAI1 and GNAI3. GRCh38: Ensembl release 89:...
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