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Guanethidine information


Guanethidine
Skeletal formula of guanethidine
Ball-and-stick model of the guanethidine molecule
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa600027
ATC code
  • C02CC02 (WHO) S01EX01 (WHO)
Pharmacokinetic data
Elimination half-life1.5 days
Identifiers
IUPAC name
  • 2-[2-(azocan-1-yl)ethyl]guanidine
CAS Number
  • 645-43-2 checkY
PubChem CID
  • 3518
IUPHAR/BPS
  • 7194
DrugBank
  • DB01170 checkY
ChemSpider
  • 3398 checkY
UNII
  • 5UBY8Y002G
KEGG
  • D08030 ☒N
ChEBI
  • CHEBI:5557 checkY
ChEMBL
  • ChEMBL765 checkY
CompTox Dashboard (EPA)
  • DTXSID5023116 Edit this at Wikidata
ECHA InfoCard100.000.220 Edit this at Wikidata
Chemical and physical data
FormulaC10H22N4
Molar mass198.314 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • N(=C(\N)N)\CCN1CCCCCCC1
InChI
  • InChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13) checkY
  • Key:ACGDKVXYNVEAGU-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine. Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine. It may also inhibit the release of granules by decreasing norepinephrine.

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Guanethidine

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Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine. Guanethidine is transported across the sympathetic...

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Sympatholytic

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can act to inhibit sympathetic function. Such drugs include bretylium, guanethidine and 6-hydroxydopamine. Many antiadrenergic agents used as antihypertensives...

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Phentermine

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Phentermine may decrease the effect of drugs like clonidine, methyldopa, and guanethidine. Drugs to treat hypothyroidism may increase the effect of phentermine...

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Priapism

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Anticoagulants (heparin and warfarin). Antihypertensives (i.e., hydralazine, guanethidine and propranolol). Hormones (i.e., gonadotropin releasing hormone and...

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Debrisoquine

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a derivative of guanidine. It is an antihypertensive drug similar to guanethidine. Debrisoquine is frequently used for phenotyping the CYP2D6 enzyme, a...

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Parotitis

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disorders such as pellagra or kwashiorkor, or have taken drugs such as guanethidine, thioridazine, or isoprenaline.[citation needed] Sarcoidosis: The lungs...

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Methamphetamine

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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MDMA

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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ATC code C02

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Trimazosin C02CA04 Doxazosin C02CA06 Urapidil C02CC01 Betanidine C02CC02 Guanethidine C02CC03 Guanoxan C02CC04 Debrisoquine C02CC05 Guanoclor C02CC06 Guanazodine...

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Amitriptyline

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nortriptyline by 33%. Amitriptiline counteracts the antihypertensive action of guanethidine. When given with amitriptyline, other anticholinergic agents may result...

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Mephedrone

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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Pseudoephedrine

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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Lisdexamfetamine

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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Nortriptyline

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(Rhythmol), or quinidine (Cardioquin, Quinidex, Quinaglute) cimetidine guanethidine reserpine Nortriptyline is a strong norepinephrine reuptake inhibitor...

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Bethanidine

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BN, Johnston AW, Hill ID, Rosenheim ML (January 1968). "Bethanidine, Guanethidine, and Methyldopa in Treatment of Hypertension: a Within-patient Comparison"...

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Chlorpromazine

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depression. Likewise, it may also antagonize the effects of clonidine and guanethidine. It also may reduce the seizure threshold and hence a corresponding titration...

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Haloperidol

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action antagonized, paradoxical decrease in blood pressure may result Guanethidine: antihypertensive action antagonized Levodopa: decreased action of levodopa...

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Azocane

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is azocine. Although azocane has limited uses, it is used in the preparation of guanethidine and trocimine. Heptamethyleneimine at Sigma-Aldrich v t e...

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Amphetamine

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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Dextroamphetamine

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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Fenethylline

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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Ephedrine

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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Schedule H

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GLYCOPYRROLATE 231. GLYDIAZINAMIDE 232. GOSERELIN ACETATE 233. GRANISETRON 234. GUANETHIDINE 235. GUGULIPID 236. HALOGENATED HYDROXYQUINOLINES 237. HALOPERIDOL 238...

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Substituted amphetamine

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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Dosulepin

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barbiturates, tranquilizers and CNSTooltip central nervous system depressants. Guanethidine and other adrenergic neuron blocking drugs can have their antihypertensive...

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Tyramine

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Adrenergic release blockers: Bethanidine Bretylium Guanadrel Guanazodine Guanethidine Guanoxan See also: Receptor/signaling modulators • Monoamine reuptake...

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