This article may be confusing or unclear to readers. In particular, the lead states that weight loss stops after a few weeks, but "Medical use" states that it continues to occur "through the ninth month", so which is it?. Please help clarify the article. There might be a discussion about this on the talk page.(May 2021) (Learn how and when to remove this template message)
Phentermine
Clinical data
Trade names
Ionamin, Suprenza, others
Other names
α-methyl-amphetamine α,α-dimethylphenethylamine
AHFS/Drugs.com
Monograph
MedlinePlus
a682187
Pregnancy category
AU: B3
Dependence liability
Physical: not typical
Psychological: Moderate[1]
Addiction liability
Low[2]
Routes of administration
By mouth
Drug class
Appetite suppressant[3]
ATC code
A08AA01 (WHO)
Legal status
Legal status
AU: S4 (Prescription only)
BR: Class B2 (Anorectic drugs)[4]
CA: Schedule IV
DE: Prescription only (Anlage III for higher doses)
Phentermine (phenyl-tertiary-butyl amine), sold under the brand name Ionamin among others, is a medication used together with diet and exercise to treat obesity.[3] It is taken by mouth for up to a few weeks at a time, after which the benefits subside.[3] It is also available as the combination phentermine/topiramate.[6]
Common side effects include a fast heart beat, high blood pressure, trouble sleeping, dizziness, and restlessness.[3] Serious side effects may include abuse, but do not include pulmonary hypertension or valvular heart disease, as the latter were caused by the fenfluramine component of the fen-phen drug combination.[3] Use is not recommended during pregnancy or breastfeeding,[7] or with SSRIs or MAO inhibitors.[3] It works mainly as an appetite suppressant, likely as a result of being a CNS stimulant.[3] Chemically, phentermine is a substituted amphetamine.[8]
Phentermine was approved for medical use in the United States in 1959.[3] It is available as a generic medication.[3] In 2021, it was the 207th most commonly prescribed medication in the United States, with more than 2million prescriptions.[9][10] Phentermine was withdrawn from the market in the United Kingdom in 2000, while the combination medication fen-phen, of which it was a part, was withdrawn from the market in 1997 due to side effects[11] of fenfluramine which caused increased levels of circulating serotonin which stimulated serotonin receptors on heart valves and thus causing valve insufficiency and leading to primary pulmonary hypertension (PPH). According to the NIH (National Institutes of Health) there is no evidence that phentermine causes PPH.[citation needed]
^Tarascon Pocket Pharmacopoeia 2017 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. 2016. p. 7. ISBN 9781284118971.
^Sadock BJ, Sadock VA (2010). Kaplan and Sadock's Pocket Handbook of Clinical Psychiatry. Lippincott Williams & Wilkins. p. 435. ISBN 9781605472645.
^ abcdefghi"Phentermine Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 13 April 2019.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ abcdCite error: The named reference TGA was invoked but never defined (see the help page).
^"Phentermine and topiramate Uses, Side Effects & Warnings". Drugs.com. Retrieved 13 April 2019.
^"Phentermine Use During Pregnancy". Drugs.com. Retrieved 13 April 2019.
^Hagel JM, Krizevski R, Marsolais F, Lewinsohn E, Facchini PJ (July 2012). "Biosynthesis of amphetamine analogs in plants". Trends in Plant Science. 17 (7): 404–412. doi:10.1016/j.tplants.2012.03.004. PMID 22502775.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Phentermine - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
^Bagchi D, Preuss HG (2012). Obesity: Epidemiology, Pathophysiology, and Prevention (Second ed.). CRC Press. p. 314. ISBN 9781439854259.
Phentermine (phenyl-tertiary-butyl amine), sold under the brand name Ionamin among others, is a medication used together with diet and exercise to treat...
loss both alone under the brand name Pondimin and in combination with phentermine commonly known as fen-phen. Side effects of fenfluramine in people treated...
Etilamfetamine Fenfluramine† (one of the two components [the other being phentermine] of Fen-phen. Since discontinued to its potential for causing valvulopathies...
loss. Fastin was once a brand name of a drug called phentermine and the Fastin brand of phentermine was manufactured by King Pharmaceuticals. Fastin and...
third party, DesignWrite, to prepare. The drug combination fenfluramine/phentermine, usually called "fen-phen," was an anti-obesity treatment. Fenfluramine...
is the 4-chloro derivative of the better known appetite suppressant phentermine, which is still in current use. Chlorphentermine acts as a highly selective...
18% with phentermine, while feelings of relaxation occurred in 5% with placebo, 5 to 19% with solriamfetol, and 15 to 20% with phentermine. As such,...
Dimethylphenethylamine may refer to: α,α-Dimethylphenethylamine (phentermine) N,α-Dimethylphenethylamine (methamphetamine) N,β-Dimethylphenethylamine...
was stood down from racing after she had tested positive for the drug phentermine, an appetite suppressant banned under Australian Rule of Racing 81B....
induced by taking antipsychotic medications. In 2012, the combination of phentermine/topiramate was approved in the United States for weight loss. People...
abbreviation for the chemical compound phenanthroline Phen, an abbreviation for phentermine in the pharmaceutical drug known as fen-phen Phen District, a district...
of phentermine and topiramate, two existing weight-loss drugs. On July 17, 2012, The U.S. Food and Drug Administration approved Qsymia (phentermine and...
August 3, 2011. He died from acute drug intoxication and heart disease. Phentermine, a weight-loss drug, was found in his system. His heart weighed more...
phenpentermine or α,β-dimethylamphetamine, is a stimulant drug related to phentermine which is used as an anorectic to assist with weight loss. It also acts...
It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermine. Clortermine...
appetite suppressant drugs such as fenfluramine (which in combination with phentermine was marketed as Pondimin and commonly referred to as fen-phen), chlorphentermine...