Nortriptyline, sold under the brand name Aventyl, among others, is a tricyclic antidepressant. This medicine is also sometimes used for neuropathic pain, attention deficit hyperactivity disorder (ADHD), smoking cessation and anxiety.[5][6] As with many antidepressants, its use for young people with depression and other psychiatric disorders may be limited due to increased suicidality in the 18–24 population initiating treatment.[6] Nortriptyline is a less preferred treatment for ADHD and stopping smoking.[6] It is taken by mouth.[6]
Common side effects include dry mouth, constipation, blurry vision, sleepiness, low blood pressure with standing, and weakness.[6] Serious side effects may include seizures, an increased risk of suicide in those less than 25 years of age, urinary retention, glaucoma, mania, and a number of heart issues.[6] Nortriptyline may cause problems if taken during pregnancy.[6] Use during breastfeeding appears to be relatively safe.[5] It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine.[6][a]
Nortriptyline was approved for medical use in the United States in 1964.[6] It is available as a generic medication.[5] In 2021, it was the 139th most commonly prescribed medication in the United States, with more than 4million prescriptions.[7][8]
^"Nortriptyline Use During Pregnancy". Drugs.com. 22 June 2020. Retrieved 10 October 2020.
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^"Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
^ abcdeLemke TL, Williams DA (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 588–. ISBN 978-1-60913-345-0.
^ abcBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 374. ISBN 9780857113382.
^ abcdefghi"Nortriptyline Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 22 March 2019.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Nortriptyline - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
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Nortriptyline, sold under the brand name Aventyl, among others, is a tricyclic antidepressant. This medicine is also sometimes used for neuropathic pain...
degree, by CYP3A4. Nortriptyline, the main active metabolite of amitriptyline, is an antidepressant on its own right. Nortriptyline reaches 10% higher...
chronic hiccups, ciguatera poisoning, and as an adjunct in schizophrenia. Nortriptyline and desipramine may be preferred medications over other TCAs among older...
used for quitting smoking include bupropion, varenicline, cytisine, nortriptyline, and clonidine and psychedelics. Treatments other than medication, such...
dosage or strength. For example GPI 58-20-00-60-10-01-05 is for the drug nortriptyline HCl cap 10 mg (an antidepressant) and can be further classified as follows:...
TCA. Most are non-toxic at less than 5 mg/kg except for desipramine, nortriptyline, and trimipramine, which are generally non-toxic at less than 2.5 mg/kg...
of the antipsychotic fluphenazine and the tricyclic antidepressant nortriptyline) to combat his anxiety, it is unclear if these substances interacted...
contrast to many other TCAs. Secondary amine TCAs like desipramine and nortriptyline have a lower risk of orthostatic hypotension than other TCAs, although...
SSRI fluoxetine, and tricyclic antidepressants (TCAs) amitriptyline, nortriptyline and imipramine. Sertraline has much lower rates of adverse effects than...
Commonly used medications include tricyclic antidepressants (such as nortriptyline, amitriptyline. imapramine, and desipramine,) serotonin-norepinephrine...
treated with certain antidepressants such as nortriptyline. However, the analgesic effect of nortriptyline, as well as amitriptyline in chronic tension-type...
and clomipramine are tricyclic antidepressants and tertiary amines. Nortriptyline, desipramine, and amoxapine are tricyclic antidepressants and secondary...
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