negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of skeletal muscle cell differentiation
glycosaminoglycan catabolic process
glycosaminoglycan biosynthetic process
Schwann cell differentiation
leukocyte migration
regulation of signal transduction
cell migration
regulation of protein localization to membrane
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2817
14733
Ensembl
ENSG00000063660
ENSMUSG00000034220
UniProt
P35052
Q9QZF2
RefSeq (mRNA)
NM_002081
NM_016696
RefSeq (protein)
NP_002072
NP_057905
Location (UCSC)
Chr 2: 240.44 – 240.47 Mb
Chr 1: 92.76 – 92.79 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Glypican-1 (GPC1) is a protein that in humans is encoded by the GPC1 gene.[5][6] GPC1 is encoded by human GPC1 gene located at 2q37.3.[7] GPC1 contains 558 amino acids with three predicted heparan sulfate chains.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000063660 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000034220 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Vermeesch JR, Mertens G, David G, Marynen P (January 1995). "Assignment of the human glypican gene (GPC1) to 2q35-q37 by fluorescence in situ hybridization". Genomics. 25 (1): 327–329. doi:10.1016/0888-7543(95)80152-C. PMID 7774946.
^"Entrez Gene: GPC1 glypican 1".
^ abPan J, Ho M (November 2021). "Role of glypican-1 in regulating multiple cellular signaling pathways". American Journal of Physiology. Cell Physiology. 321 (5): C846–C858. doi:10.1152/ajpcell.00290.2021. PMC 8616591. PMID 34550795.
Glypican-1 (GPC1) is a protein that in humans is encoded by the GPC1 gene. GPC1 is encoded by human GPC1 gene located at 2q37.3. GPC1 contains 558 amino...
Glypicans constitute one of the two major families of heparan sulfate proteoglycans, with the other major family being syndecans. Six glypicans have been...
Glypican-3 is a protein that, in humans, is encoded by the GPC3 gene. The GPC3 gene is located on human X chromosome (Xq26) where the most common gene...
possible association with deletion of the gene GPC1, which encodes a glypican1-a heparan sulfate proteoglycan, has been reported. This gene is located...
Glypican-6 is a protein that in humans is encoded by the GPC6 gene. The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate...
Glypican-5 is a protein that in humans is encoded by the GPC5 gene. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein...
Glypican-4 is a protein that in humans is encoded by the GPC4 gene. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein...
humans is encoded by the SLIT2 gene. SLIT2 has been shown to interact with Glypican1. GRCh38: Ensembl release 89: ENSG00000145147 – Ensembl, May 2017 GRCm38:...
expressed doubt regarding the involvement of PTEN or GPC3, which codes for glypican 3 and may play a role in regulating cell division and growth regulation...
Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain". The Journal of Biological Chemistry. 274 (25): 17885–92. doi:10...
Glypican 2 (GPC2), also known cerebroglycan, is a protein which in humans is encoded by the GPC2 gene. The GPC2 gene is at locus 7q22.1 and encodes for...
2012). "High-affinity monoclonal antibodies to cell surface tumor antigen glypican-3 generated through a combination of peptide immunization and flow cytometry...
exploring T cells engineered with chimeric antigen receptors (CARs) targeting glypican-3 (GPC3), such as GAP T cells, showing potential in addressing GPC3-positive...
receptor through the binding of proteins such as the stabilizers Dally and glypican 3 (GPC3), which inhibit diffusion. In cancer cells, both the heparan sulfate...
transmembrane syndecans and the glycosylphosphatidylinositol (GPI) anchored glypicans. Other minor forms of membrane HSPG include betaglycan and the V-3 isoform...
not been positively identified. The GPI-anchored cell surface protein glypican-3 (GPC3) is known to interact with Fat1 in human liver cancer. GPC3 is...
(October 2011). "Advances in liver cancer antibody therapies: a focus on glypican-3 and mesothelin". BioDrugs. 25 (5): 275–284. doi:10.2165/11595360-000000000-00000...
gene and the glypican 6 gene in the 13q31.3 region, as well as EFNB2 and the collagen type IV a1 chain (COL4A1) and COL4A2 genes in the 13q33.1-q34 region...
brought cancer metabolism back to the forefront of cancer biology. On August 1,[year needed] Agios announced that the FDA had approved their lead compound...
identifies five microRNAs controlling glypican-3: role of miR-1271 down-regulation in hepatocellular carcinoma". Hepatology. 57 (1): 195–204. doi:10.1002/hep.25994...
atypical cadherin FAT1 as a novel glypican-3 interacting protein in liver cancer cells". Scientific Reports. 11 (1): 40. doi:10.1038/s41598-020-79524-3...
model) and 35% diffuse slowly (consistent with Dpp bound to receptors or glypicans). The restricted diffusion model includes the effects of cell packing...
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