Mesothelin information

MSLN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F3F
Identifiers
Aliases	MSLN, MPF, SMRP, mesothelin
External IDs	OMIM: 601051 MGI: 1888992 HomoloGene: 4249 GeneCards: MSLN
Gene location (Human)
Chr.	Chromosome 16 (human)
End	768,865 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	25,973,352 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right lung; ; upper lobe of left lung; ; germinal epithelium; ; palpebral conjunctiva; ; pericardium; ; trachea; ; peritoneum; ; left uterine tube; ; lower lobe of lung;
	Top expressed in
	left lung lobe; ; belly cord; ; pericardial cavity; ; trachea; ; atrioventricular valve; ; olfactory epithelium; ; sciatic nerve; ; fundus; ; superior surface of tongue; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cell surface; anchored component of membrane; Golgi apparatus; membrane; extracellular region; extracellular space; plasma membrane; endoplasmic reticulum lumen;
Biological process	pancreas development; cell adhesion; cell-matrix adhesion; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	10232
	56047
	ENSG00000102854
	ENSMUSG00000063011
	Q13421
	Q61468
	NM_001177355; NM_005823; NM_013404
	NM_018857; NM_001356286; NM_001374653
	NP_001170826; NP_005814; NP_037536
	NP_061345; NP_001343215
	Wikidata
View/Edit Human	View/Edit Mouse

Mesothelin, also known as MSLN, is a protein that in humans is encoded by the MSLN gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102854 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063011 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kojima T, Oh-eda M, Hattori K, Taniguchi Y, Tamura M, Ochi N, Yamaguchi N (September 1995). "Molecular cloning and expression of megakaryocyte potentiating factor cDNA". The Journal of Biological Chemistry. 270 (37): 21984–21990. doi:10.1074/jbc.270.37.21984. PMID 7665620.
^ Chang K, Pastan I (January 1996). "Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers". Proceedings of the National Academy of Sciences of the United States of America. 93 (1): 136–140. Bibcode:1996PNAS...93..136C. doi:10.1073/pnas.93.1.136. PMC 40193. PMID 8552591.

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