Key morphogen involved in the development of the fruit fly Drosophila melanogaster
Decapentaplegic
Identifiers
Organism
Drosophila melanogaster
Symbol
Dpp
UniProt
P07713
Search for
Structures
Swiss-model
Domains
InterPro
Decapentaplegic (Dpp) is a key morphogen involved in the development of the fruit fly Drosophila melanogaster and is the first validated secreted morphogen.[1] It is known to be necessary for the correct patterning and development of the early Drosophila embryo and the fifteen imaginal discs, which are tissues that will become limbs and other organs and structures in the adult fly. It has also been suggested that Dpp plays a role in regulating the growth and size of tissues. Flies with mutations in decapentaplegic fail to form these structures correctly, hence the name (decapenta-, fifteen, -plegic, paralysis). Dpp is the Drosophila homolog of the vertebrate bone morphogenetic proteins (BMPs), which are members of the TGF-β superfamily, a class of proteins that are often associated with their own specific signaling pathway. Studies of Dpp in Drosophila have led to greater understanding of the function and importance of their homologs in vertebrates like humans.
Decapentaplegic (Dpp) is a key morphogen involved in the development of the fruit fly Drosophila melanogaster and is the first validated secreted morphogen...
Mothers against decapentaplegic is a protein from the SMAD family that was discovered in Drosophila. During Drosophila research, it was found that a mutation...
Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene. SMAD1...
effect mutations that caused lethality of heterozygous decapentaplegic progeny. Because decapentaplegic is a bone morphogenetic protein in the transforming...
distal-less) decapentaplegic triggers cell shape changes in the gut that are required for normal visceral morphology ULTRABITHORAX (activates decapentaplegic) reaper...
Mothers against decapentaplegic homolog 2, also known as SMAD family member 2 or SMAD2, is a protein that in humans is encoded by the SMAD2 gene. MAD...
Mothers against decapentaplegic homolog 9 also known as SMAD9, SMAD8, and MADH6 is a protein that in humans is encoded by the SMAD9 gene. SMAD9, as its...
Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. SMAD7 is a protein that, as its name describes...
Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene. SMAD5, as its name describes,...
name describes, is a homolog of the Drosophila gene "mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ...
SMAD4, also called SMAD family member 4, Mothers against decapentaplegic homolog 4, or DPC4 (Deleted in Pancreatic Cancer-4) is a highly conserved protein...
behavior of filopodia with a known morphogen signaling protein - decapentaplegic. Decapentaplegic is expressed in the wing disc by cells that function as a developmental...
Stephen Cohen then demonstrated that a secreted signalling protein, decapentaplegic (the Drosophila homologue of transforming growth factor beta), acted...
intelligence model trained on synthetic data intelligence Mothers against decapentaplegic, a protein MPEG Audio Decoder, software Multi-conjugate Adaptive optics...
into the soil. Soil was woodchip-heavy. bacteriophage Mothers against decapentaplegic 1–9, and the associated Daughters against dpp Takes the name from "Mothers...
transcription factors twist and snail while repressing zerknüllt and decapentaplegic. This results in the formation of the mesoderm. In the lateral regions...
Hong Kong Democratic Party for the People, a Japanese political party Decapentaplegic, a morphogen involved in development Diketopyrrolopyrrole dye, a class...
Mothers against decapentaplegic homolog 3 also known as SMAD family member 3 or SMAD3 is a protein that in humans is encoded by the SMAD3 gene. SMAD3...
signals. Studies in Drosophila germarium have identified the signals decapentaplegic and adherens junctions that prevent germarium stem cells from differentiating...
Stephen Cohen, then demonstrated that a secreted signaling protein, Decapentaplegic (the Drosophila homologue of transforming growth factor beta), acted...
patients directly rather than billing insurance companies Mothers against decapentaplegic homolog 4 or Deleted in Pancreatic Cancer-4 (DPC4), a cell signaling...
family, exhibiting homology with the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. Functioning as a crucial signal...
bmp-like factors such as bmp 2/4, which is homologous to Drosophila’s decapentaplegic dpp. The expression of bmp2/4 begins at the onset of gastrulation on...
is controlled both by transcription factors (such as engrailed and decapentaplegic) and by developmental rate. The simplification of a shell form is thought...
"inappropriateness" of the names of genes such as "Mothers against decapentaplegic," "Lunatic fringe," and "Sonic hedgehog" is largely avoided by using...
He was best known for his work with fly genetics, the discovery of decapentaplegic (dpp), and the formation of FlyBase. He was a member of the National...
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