Glypican 2 information

GPC2
Identifiers
Aliases	GPC2, Glypican 2
External IDs	OMIM: 618446 MGI: 1919201 HomoloGene: 17657 GeneCards: GPC2
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,177,381 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	138,278,267 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; sperm; ; pericardium; ; thymus; ; skin of abdomen; ; ventral tegmental area; ; nipple; ; globus pallidus; ; internal globus pallidus; ; saphenous vein;
	Top expressed in
	ganglionic eminence; ; mesencephalon; ; neural tube; ; spermatocyte; ; lens; ; peripheral nervous system; ; rhombencephalon; ; respiratory epithelium; ; sensory ganglion; ; autonomic nervous system;
	More reference expression data
	n/a
Gene ontology
Molecular function	heparan sulfate proteoglycan binding; protein binding;
Cellular component	membrane; plasma membrane; extracellular region; lysosomal lumen; endoplasmic reticulum; Golgi lumen; anchored component of membrane; extracellular space; anchored component of plasma membrane; collagen-containing extracellular matrix; cell surface; synapse;
Biological process	retinoid metabolic process; glycosaminoglycan catabolic process; glycosaminoglycan biosynthetic process; neuron differentiation; smoothened signaling pathway; regulation of signal transduction; positive regulation of neuron projection development; cell migration; regulation of protein localization to membrane;
	Sources:Amigo / QuickGO
Orthologs
	221914
	71951
	ENSG00000213420
	ENSMUSG00000029510
	Q8N158
	Q8BKV1
	NM_152742
	NM_172412
	NP_689955
	NP_766000
	Wikidata
View/Edit Human	View/Edit Mouse

Glypican 2 (GPC2), also known cerebroglycan, is a protein which in humans is encoded by the GPC2 gene.^[5]^[6] The GPC2 gene is at locus 7q22.1 and encodes for a 579 amino acid protein.^[7] The C-terminus of GPC2 has the GPI attachment site, at G554, and the N-terminus encodes a signal peptide, from M1 to S24. Multiple GPC2 mRNA transcripts have been identified.^[8] GPC2-201 is the isoform overexpressed in pediatric cancers. Tumor-associated exon 3 of GPC2 shows the lowest expression in normal tissues compared with other exons.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213420 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029510 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stipp CS, Litwack ED, Lander AD (January 1994). "Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation". The Journal of Cell Biology. 124 (1–2): 149–160. doi:10.1083/jcb.124.1.149. PMC 2119891. PMID 8294498.
^ "Entrez Gene: GPC2 glypican 2".
^ Li N, Spetz MR, Li D, Ho M (July 2021). "Advances in immunotherapeutic targets for childhood cancers: A focus on glypican-2 and B7-H3". Pharmacology & Therapeutics. 223: 107892. doi:10.1016/j.pharmthera.2021.107892. PMC 8202769. PMID 33992682.
^ ^a ^b Li N, Torres MB, Spetz MR, Wang R, Peng L, Tian M, et al. (June 2021). "CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice". Cell Reports. Medicine. 2 (6): 100297. doi:10.1016/j.xcrm.2021.100297. PMC 8233664. PMID 34195677.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213420 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029510 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8294498-5] Stipp CS, Litwack ED, Lander AD (January 1994). "Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation". The Journal of Cell Biology. 124 (1–2): 149–160. doi:10.1083/jcb.124.1.149. PMC 2119891. PMID 8294498.

[entrez-6] "Entrez Gene: GPC2 glypican 2".

[7] Li N, Spetz MR, Li D, Ho M (July 2021). "Advances in immunotherapeutic targets for childhood cancers: A focus on glypican-2 and B7-H3". Pharmacology & Therapeutics. 223: 107892. doi:10.1016/j.pharmthera.2021.107892. PMC 8202769. PMID 33992682.

[:0-8] Li N, Torres MB, Spetz MR, Wang R, Peng L, Tian M, et al. (June 2021). "CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice". Cell Reports. Medicine. 2 (6): 100297. doi:10.1016/j.xcrm.2021.100297. PMC 8233664. PMID 34195677.

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